PMID- 11435997
OWN - NLM
STAT- MEDLINE
DCOM- 20010927
LR  - 20220225
IS  - 0003-410X (Print)
IS  - 0003-410X (Linking)
VI  - 152 Suppl 3
DP  - 2001 Apr
TI  - Involvement of free radicals in MDMA-induced neurotoxicity in mice.
PG  - IS57-9
AB  - 3,4-methylenedioxymethamphetamine (MDMA) or ecstasy) is a substituted amphetamine 
      with stimulating and hallucinogenic properties. Administration of MDMA leads to 
      the formation of metabolites responsible for its toxic effects on serotonergic 
      neurons in rats and non-human primates and on dopaminergic neurons in mice. Our 
      findings indicate that overexpression of the human superoxide dismutase gene 
      (Cu/Zn-SOD) abolishes certain effects of MDMA such as the decreased level of 
      dopamine, DOPAC and 5-HT in the striatum, inactivation of certain antioxidant 
      enzymes (CU/ZN-SPD, catalase or glutathione peroxidase) or peroxidation of 
      lipids. These data are in agreement with the implication of free radicals and 
      consequenty of oxidative stress in the mode of action of MDMA.
FAU - Cadet, J L
AU  - Cadet JL
AD  - Molecular Neuropsychiatry Section, Division of Intramural Research, Baltimore, MD 
      21224, USA.
FAU - Thiriet, N
AU  - Thiriet N
FAU - Jayanthi, S
AU  - Jayanthi S
LA  - eng
PT  - Journal Article
PL  - France
TA  - Ann Med Interne (Paris)
JT  - Annales de medecine interne
JID - 0171744
RN  - 0 (Free Radicals)
RN  - 0 (Hallucinogens)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Brain Chemistry/drug effects
MH  - Catalase/drug effects/metabolism
MH  - *Disease Models, Animal
MH  - Free Radicals/*adverse effects/metabolism
MH  - Gene Expression Regulation/genetics
MH  - Glutathione Peroxidase/drug effects/metabolism
MH  - Hallucinogens/*adverse effects/metabolism
MH  - Lipid Peroxidation/drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*adverse effects/metabolism
MH  - Neurotoxicity Syndromes/*etiology/metabolism/pathology
MH  - Oxidative Stress
MH  - Superoxide Dismutase/drug effects/genetics/metabolism
EDAT- 2001/07/04 10:00
MHDA- 2001/09/28 10:01
CRDT- 2001/07/04 10:00
PHST- 2001/07/04 10:00 [pubmed]
PHST- 2001/09/28 10:01 [medline]
PHST- 2001/07/04 10:00 [entrez]
AID - 60255 [pii]
PST - ppublish
SO  - Ann Med Interne (Paris). 2001 Apr;152 Suppl 3:IS57-9.