PMID- 11436357
OWN - NLM
STAT- MEDLINE
DCOM- 20010830
LR  - 20120531
IS  - 0914-7470 (Print)
IS  - 0914-7470 (Linking)
VI  - 14
IP  - 1
DP  - 2001 Mar
TI  - Pericellular activation of hepatocyte growth factor/scatter factor (HGF/SF) in 
      colorectal carcinomas: roles of HGF activator (HGFA) and HGFA inhibitor type 1 
      (HAI-1).
PG  - 83-93
AB  - Activation of hepatocyte growth factor/scatter factor (HGF/SF) is a critical 
      limiting step in the HGF/SF-induced signaling pathway mediated by MET receptor 
      tyrosine kinase. Although HGF/SF-MET signaling could have potentially important 
      roles in the invasive growth of tumors and tumor angiogenesis, little is known 
      about the regulation of HGF/SF activation in the tumor tissues. This activation 
      occurs in the extracellular milieu caused by proteolytic cleavage at the bond 
      between Arg194-Val195 in the single-chain HGF precursor to generate the active 
      two-chain heterodimeric form. Here we show that activation of HGF/SF is 
      significantly enhanced in colorectal carcinoma tissues compared with normal 
      colorectal mucosa, and HGF activator (HGFA), a recently identified factor 
      XII-like serine proteinase, is critically involved in this process. Furthermore, 
      we also show that HGF activator inhibitor type 1 (HAI-1) should have an important 
      regulatory role in the pericellular activation of HGF/SF having diverse roles 
      acting as a cell surface specific inhibitor of active HGFA and a reservoir of 
      this enzyme on the cell surface. The latter property might paradoxically ensure 
      the concentrated pericellular HGFA activity in certain cellular conditions in 
      which shedding of HAI-1/HGFA complex from the plasma membrane is upregulated.
FAU - Kataoka, H
AU  - Kataoka H
AD  - Second Department of Pathology, Miyazaki Medical College.
FAU - Itoh, H
AU  - Itoh H
FAU - Hamasuna, R
AU  - Hamasuna R
FAU - Meng, J Y
AU  - Meng JY
FAU - Koono, M
AU  - Koono M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Japan
TA  - Hum Cell
JT  - Human cell
JID - 8912329
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Proteinase Inhibitory Proteins, Secretory)
RN  - 0 (SPINT1 protein, human)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 3.4.21.- (HGF activator)
RN  - EC 3.4.21.- (Serine Endopeptidases)
SB  - IM
MH  - Adenocarcinoma/*metabolism/pathology
MH  - Colorectal Neoplasms/*metabolism/pathology
MH  - Hepatocyte Growth Factor/*metabolism/physiology
MH  - Humans
MH  - Membrane Glycoproteins/*physiology
MH  - Proteinase Inhibitory Proteins, Secretory
MH  - Serine Endopeptidases/*physiology
MH  - Signal Transduction
MH  - Up-Regulation
RF  - 47
EDAT- 2001/07/05 10:00
MHDA- 2001/08/31 10:01
CRDT- 2001/07/05 10:00
PHST- 2001/07/05 10:00 [pubmed]
PHST- 2001/08/31 10:01 [medline]
PHST- 2001/07/05 10:00 [entrez]
PST - ppublish
SO  - Hum Cell. 2001 Mar;14(1):83-93.