PMID- 11436507
OWN - NLM
STAT- MEDLINE
DCOM- 20011018
LR  - 20110726
IS  - 0301-4894 (Print)
IS  - 0301-4894 (Linking)
VI  - 102
IP  - 6
DP  - 2001 Jun
TI  - [Treatment of lymph node metastasis from the viewpoint of surgical oncology].
PG  - 453-8
AB  - We have investigated methods to predict lymph node metastasis in early gastric 
      cancer. First, the efficacy of fluorescence in situ hybridization (FISH) using 
      the dual-color method was evaluated as a potential marker of lymph node 
      metastasis in 20 early gastric cancers. A significant increase in the fraction of 
      cells with a decrease in p53 was observed in early gastric cancer compared with 
      normal tissues. More importantly, a significant increase in the fraction of cells 
      with p53 deletion was observed in patients with lymph node metastasis. The 
      predictive accuracy was 45%. Second, the relationship between the degree of 
      expression of biological markers and lymph node metastasis was examined. High 
      expression of p27 and cyclin E had a strong correlation with lymph node 
      metastasis. Moreover, all patients with combined high expression of p27, cyclin 
      E, and matrix metalloproteinase-9 had lymph node metastasis. However, these 
      represented only 21% of cases with lymph node metastasis. Difficulty in the 
      clinical use of these biological markers to detect lymph node metastasis depends 
      on the feedback mechanism of cell cycle regulators or heterogeneity of the 
      lesion. These problems should be resolved in the near feature.
FAU - Hirai, T
AU  - Hirai T
AD  - Department of Surgical Oncology, Research Institute for Radiation Biology and 
      Medicine, Hiroshima University, Hiroshima, Japan.
FAU - Toge, T
AU  - Toge T
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nihon Geka Gakkai Zasshi
JT  - Nihon Geka Gakkai zasshi
JID - 0405405
RN  - 0 (CDKN1A protein, human)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Cyclin E)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p21)
RN  - 0 (Cyclins)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - 0 (Tumor Suppressor Proteins)
RN  - 147604-94-2 (Cyclin-Dependent Kinase Inhibitor p27)
SB  - IM
MH  - Cell Cycle Proteins/biosynthesis
MH  - Cyclin E/biosynthesis
MH  - Cyclin-Dependent Kinase Inhibitor p21
MH  - Cyclin-Dependent Kinase Inhibitor p27
MH  - Cyclins/biosynthesis
MH  - Humans
MH  - *Lymph Node Excision
MH  - Lymphatic Metastasis/*pathology
MH  - Stomach Neoplasms/*pathology/surgery
MH  - Tumor Suppressor Protein p53/biosynthesis
MH  - *Tumor Suppressor Proteins
EDAT- 2001/07/05 10:00
MHDA- 2001/10/19 10:01
CRDT- 2001/07/05 10:00
PHST- 2001/07/05 10:00 [pubmed]
PHST- 2001/10/19 10:01 [medline]
PHST- 2001/07/05 10:00 [entrez]
PST - ppublish
SO  - Nihon Geka Gakkai Zasshi. 2001 Jun;102(6):453-8.