PMID- 11436982
OWN - NLM
STAT- MEDLINE
DCOM- 20011101
LR  - 20190607
IS  - 0916-8737 (Print)
IS  - 0916-8737 (Linking)
VI  - 37
IP  - 1
DP  - 2001 Feb
TI  - Difference in effects of stretch on depressive effect of endothelium-derived 
      nitric oxide on noradrenaline- and high-K+-induced contractions between the 
      aortae from normotensive and spontaneously hypertensive rats.
PG  - 9-23
AB  - Difference in effects of stretch tension on endothelium-derived nitric oxide 
      (EDNO)-dependent depression of noradrenaline (NA)- and high-K+-induced 
      contraction between the aortae from normotensive Wistar Kyoto rats (WKY) a nd 
      stroke-pronespontaneously hypertensive rats (SHRSP) was studied. NA-induced 
      contraction in preparations both from WKY and SHRSP was augmented in the presence 
      of N(omega)-nitro-L-arginine (L-NNA). This augmentation was minimized when the 
      spontaneous tone, which was more prominent in preparations from SHRSP, was 
      subtracted and the effects of L-NNA became less prominent in preparations from 
      SHRSP. The effects of L-NNA were maximal at the stretch tension of 15 mN and, 
      then, decreased as stretch tension increased in both preparations when the 
      spontaneous tone was subtracted. The effects of L-NNA were less prominent when 
      the contraction was initiated by high-K+, although the effects of stretch on 
      high-K+-induced contraction were similar to that of NA-induced contraction. These 
      results suggested 1) that both NA- and high-K+-induced contractions are depressed 
      by EDNO, 2) that the release of EDNO induced by high-K+ is less than that by NA, 
      3) that increase in stretch tension decreases the release of EDNO, and 4) that 
      the depressive effect of EDNO on contraction is impaired in the aorta of SHRSP.
FAU - Sekiguchi, F
AU  - Sekiguchi F
AD  - Department of Anatomy and Physiology, Faculty of Pharmaceutical Sciences, Kinki 
      University, Higashi-Osaka, Osaka, Japan. fumiko@phar.kindai.ac.jp
FAU - Miyake, Y
AU  - Miyake Y
FAU - Nakazumi, S
AU  - Nakazumi S
FAU - Shimamura, K
AU  - Shimamura K
FAU - Yamamoto, K
AU  - Yamamoto K
FAU - Sunano, S
AU  - Sunano S
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - J Smooth Muscle Res
JT  - Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi
JID - 9211664
RN  - 0 (Enzyme Inhibitors)
RN  - 2149-70-4 (Nitroarginine)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - RWP5GA015D (Potassium)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Aorta/drug effects/*physiology
MH  - Blood Pressure
MH  - Dose-Response Relationship, Drug
MH  - Endothelium, Vascular/*metabolism
MH  - Enzyme Inhibitors/pharmacology
MH  - Genetic Predisposition to Disease
MH  - Nitric Oxide/*physiology
MH  - Nitroarginine/pharmacology
MH  - Norepinephrine/*pharmacology
MH  - Potassium/*administration & dosage/pharmacology
MH  - Rats
MH  - Rats, Inbred SHR/genetics/*physiology
MH  - Rats, Inbred WKY
MH  - Reference Values
MH  - Stress, Mechanical
MH  - Stroke/genetics
MH  - Vasoconstriction/*physiology
EDAT- 2001/07/05 10:00
MHDA- 2001/11/03 10:01
CRDT- 2001/07/05 10:00
PHST- 2001/07/05 10:00 [pubmed]
PHST- 2001/11/03 10:01 [medline]
PHST- 2001/07/05 10:00 [entrez]
AID - 10.1540/jsmr.37.9 [doi]
PST - ppublish
SO  - J Smooth Muscle Res. 2001 Feb;37(1):9-23. doi: 10.1540/jsmr.37.9.