PMID- 11437498
OWN - NLM
STAT- MEDLINE
DCOM- 20010830
LR  - 20061115
IS  - 0021-9975 (Print)
IS  - 0021-9975 (Linking)
VI  - 124
IP  - 4
DP  - 2001 May
TI  - Distribution of porcine reproductive and respiratory syndrome virus in stillborn 
      and liveborn piglets from experimentally infected sows.
PG  - 231-7
AB  - Four pregnant sows were infected 3 weeks before their expected farrowing date 
      with a Korean isolate (North American genotype) of porcine reproductive and 
      respiratory syndrome virus (PRRSV). The distribution of virus in their stillborn 
      and liveborn (killed 7 days after birth) offspring was assessed 
      immunohistochemically and by in-situ hybridization. PRRSV antigen and nucleic 
      acid were detected in lung, thymus, liver, tonsil, spleen, heart, kidney and 
      lymph nodes from both stillborn and liveborn piglets. Positive cells typically 
      exhibited a red (immunohistochemistry) or dark brown (in-situ hybridization) 
      reaction product in the cytoplasm, without background staining. The most 
      consistent labelling for PRRSV was in the thymus, tonsil and lymph nodes. The 
      experiment suggested that, in prenatal piglets, PRRSV replicates primarily in 
      lymphoid tissues, having gained access to them from the placenta via the 
      bloodstream.
FAU - Cheon, D S
AU  - Cheon DS
AD  - Department of Veterinary Pathology, College of Veterinary Medicine and School of 
      Agricultural Biotechnology, Seoul National University, Suwon, Kyounggi-Do, 
      441-744, Republic of Korea.
FAU - Chae, C
AU  - Chae C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Comp Pathol
JT  - Journal of comparative pathology
JID - 0102444
SB  - IM
MH  - Animals
MH  - Animals, Newborn/*virology
MH  - Disease Models, Animal
MH  - Female
MH  - Fetal Death/*virology
MH  - Immunohistochemistry/veterinary
MH  - In Situ Hybridization/veterinary
MH  - Porcine Reproductive and Respiratory Syndrome/pathology/transmission/*virology
MH  - Porcine respiratory and reproductive syndrome virus/genetics/growth & 
      development/immunology/*isolation & purification
MH  - Pregnancy
MH  - *Swine
MH  - Virus Replication
EDAT- 2001/07/05 10:00
MHDA- 2001/08/31 10:01
CRDT- 2001/07/05 10:00
PHST- 2001/07/05 10:00 [pubmed]
PHST- 2001/08/31 10:01 [medline]
PHST- 2001/07/05 10:00 [entrez]
AID - S0021-9975(00)90457-2 [pii]
AID - 10.1053/jcpa.2000.0457 [doi]
PST - ppublish
SO  - J Comp Pathol. 2001 May;124(4):231-7. doi: 10.1053/jcpa.2000.0457.