PMID- 11438106
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 0022-0981 (Print)
IS  - 0022-0981 (Linking)
VI  - 261
IP  - 1
DP  - 2001 Jun 15
TI  - The effects of sediment-associated triorganotin compounds on the gills of the 
      European flounder, Platichthys flesus (L.).
PG  - 75-91
AB  - The effects of exposure to sediment-associated tri-n-butyltin chloride (TBT) and 
      triphenyltin chloride (TPhT) were examined in the euryhaline European flounder, 
      Platichthys flesus (L.). The effects were quantified by measuring the changes in 
      sodium efflux, Na(+)/K(+)-ATPase activity and the numbers, areas and distribution 
      of chloride cells in the gills of freshwater-adapted fish, following a rapid 
      transfer to seawater. After transfer, the Na(+)/K(+)-ATPase activity and the 
      sodium efflux significantly increased in both the TPhT and control groups but not 
      in the TBT group. However, Na(+)/K(+)-ATPase activity and the sodium efflux in 
      the TPhT group had returned to pre-salinity transfer levels by day 15 after the 
      initial exposure to TPhT. Morphological changes in the numbers and areas of 
      chloride cells, known to be associated with seawater adaptation, took place in 
      the control group, i.e. there was a significant reduction in the number of 
      lamellar chloride cells accompanied by an increase in the number of interlamellar 
      chloride cells. There was a reduction in the numbers of lamellar chloride cells 
      in the TBT-exposed group following transfer to seawater but the mean number was 
      significantly higher than the control group by the end of the experiment. In the 
      TPhT-exposed group, the reduction was not significantly different to that seen in 
      the control group. By the end of the experiment, both organotin-exposed groups 
      had significantly lower mean numbers of interlamellar chloride cells than the 
      control group. Before transfer to seawater, the mean areas of lamellar and 
      interlamellar chloride cells of all three groups were not significantly 
      different. On transfer, the mean areas of lamellar chloride cells in the control 
      group became significantly smaller than the mean areas of the organotin groups. 
      There was no significant difference in the mean areas of interlamellar chloride 
      cells in the control and TBT groups between the start and finish of the 
      experiment but there was a significant increase in the mean area of TPhT-treated 
      animals at the end of the experiment when compared to the control group. The 
      results presented in this study lead to the conclusion that tri-n-butyltin 
      chloride and triphenyltin chloride in sediments are capable of significantly 
      disrupting both the physiological as well as morphological components of ionic 
      regulatory functions of an estuarine fish, at concentrations currently found in 
      estuarine sediments.
FAU - Hartl, M GJ
AU  - Hartl MG
AD  - Southampton Oceanography Centre, School of Ocean and Earth Science, University of 
      Southampton, European Way, SO14 3ZH, Southampton, UK
FAU - Hutchinson, S
AU  - Hutchinson S
FAU - Hawkins, L E
AU  - Hawkins LE
FAU - Grand, D J
AU  - Grand DJ
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Exp Mar Biol Ecol
JT  - Journal of experimental marine biology and ecology
JID - 9879543
EDAT- 2001/07/05 10:00
MHDA- 2001/07/05 10:01
CRDT- 2001/07/05 10:00
PHST- 2001/07/05 10:00 [pubmed]
PHST- 2001/07/05 10:01 [medline]
PHST- 2001/07/05 10:00 [entrez]
AID - S0022098101002611 [pii]
AID - 10.1016/s0022-0981(01)00261-1 [doi]
PST - ppublish
SO  - J Exp Mar Biol Ecol. 2001 Jun 15;261(1):75-91. doi: 
      10.1016/s0022-0981(01)00261-1.