PMID- 11438356
OWN - NLM
STAT- MEDLINE
DCOM- 20010920
LR  - 20190712
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 73
IP  - 3
DP  - 2001 Jun
TI  - Psychosocial vs. "physical" stress situations in rodents and humans: role of 
      neurotrophins.
PG  - 313-20
AB  - Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are 
      well-studied polypeptide growth factors involved in the development and 
      maintenance of specific peripheral and central populations of neuronal cells. In 
      addition to its role as a neurotrophic agent, NGF controls very complex functions 
      in vertebrate physiology. A variety of cells outside the nervous system are in 
      fact able to synthesize NGF including epithelial cells, fibroblasts, lymphocytes, 
      and macrophages. NGF target cells have been identified in the nervous, immune, 
      and endocrine systems, suggesting that NGF may operate through multiple paths to 
      ultimately regulate physiological homeostasis and behavioral coping. We used a 
      mouse model of social stress to demonstrate that NGF levels increase both in 
      plasma and in the hypothalamus following intermale aggressive interactions. The 
      investigation has been extended to other species, including humans, to show that 
      labour, lactation, and the anticipation of the first jump with a parachute also 
      result in increased NGF plasma levels and in changes in the distribution of NGF 
      receptors on lymphocytes. BDNF activation is caused by both physical and social 
      stress events. The aim of this review is to (1) outline the current understanding 
      of the roles of NGF and BDNF in stress-related physiological changes in 
      vertebrates, in particular for physical vs. psychological stressors, which may 
      activate both similar and different neurobiological pathways, and (2) summarize 
      recent efforts to derive pharmacological strategies from the increasing body of 
      BDNF and NGF neurobehavioral data.
FAU - Alleva, E
AU  - Alleva E
AD  - Section of Behavioural Pathophysiology, Laboratorio di Fisiopatologia di Organo e 
      di Sistema, Istituto Superiore di Sanita, Viale Regina Elena, 299 I-00161, Rome, 
      Italy. alleva@iss.it
FAU - Santucci, D
AU  - Santucci D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Nerve Growth Factors/*physiology
MH  - Rats
MH  - *Social Environment
MH  - Stress, Physiological/metabolism/*physiopathology
MH  - Stress, Psychological/metabolism/*physiopathology
RF  - 80
EDAT- 2001/07/05 10:00
MHDA- 2001/09/21 10:01
CRDT- 2001/07/05 10:00
PHST- 2001/07/05 10:00 [pubmed]
PHST- 2001/09/21 10:01 [medline]
PHST- 2001/07/05 10:00 [entrez]
AID - S0031-9384(01)00498-X [pii]
AID - 10.1016/s0031-9384(01)00498-x [doi]
PST - ppublish
SO  - Physiol Behav. 2001 Jun;73(3):313-20. doi: 10.1016/s0031-9384(01)00498-x.