PMID- 11438609
OWN - NLM
STAT- MEDLINE
DCOM- 20010726
LR  - 20231014
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 21
IP  - 14
DP  - 2001 Jul 15
TI  - Negative interspike interval correlations increase the neuronal capacity for 
      encoding time-dependent stimuli.
PG  - 5328-43
AB  - Accurate detection of sensory input is essential for the survival of a species. 
      Weakly electric fish use amplitude modulations of their self-generated electric 
      field to probe their environment. P-type electroreceptors convert these 
      modulations into trains of action potentials. Cumulative relative refractoriness 
      in these afferents leads to negatively correlated successive interspike intervals 
      (ISIs). We use simple and accurate models of P-unit firing to show that these 
      refractory effects lead to a substantial increase in the animal's ability to 
      detect sensory stimuli. This assessment is based on two approaches, signal 
      detection theory and information theory. The former is appropriate for 
      low-frequency stimuli, and the latter for high-frequency stimuli. For low 
      frequencies, we find that signal detection is dependent on differences in mean 
      firing rate and is optimal for a counting time at which spike train variability 
      is minimal. Furthermore, we demonstrate that this minimum arises from the 
      presence of negative ISI correlations at short lags and of positive ISI 
      correlations that extend out to long lags. Although ISI correlations might be 
      expected to reduce information transfer, in fact we find that they improve 
      information transmission about time-varying stimuli. This is attributable to the 
      differential effect that these correlations have on the noise and baseline 
      entropies. Furthermore, the gain in information transmission rate attributable to 
      correlations exhibits a resonance as a function of stimulus bandwidth; the 
      maximum occurs when the inverse of the cutoff frequency of the stimulus is of the 
      order of the decay time constant of refractory effects. Finally, we show that the 
      loss of potential information caused by a decrease in spike-timing resolution is 
      smaller for low stimulus cutoff frequencies than for high ones. This suggests 
      that a rate code is used for the encoding of low-frequency stimuli, whereas spike 
      timing is important for the encoding of high-frequency stimuli.
FAU - Chacron, M J
AU  - Chacron MJ
AD  - Department of Physics, University of Ottawa, Ottawa, Ontario, Canada K1N-6N5. 
      mchacron@physics.uottawa.ca
FAU - Longtin, A
AU  - Longtin A
FAU - Maler, L
AU  - Maler L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
SB  - IM
MH  - Action Potentials/*physiology
MH  - Afferent Pathways/physiology
MH  - Animals
MH  - Computer Simulation
MH  - Electric Fish
MH  - Entropy
MH  - Information Theory
MH  - Markov Chains
MH  - *Models, Neurological
MH  - Neurons/*physiology
MH  - Normal Distribution
MH  - ROC Curve
MH  - Reaction Time/physiology
MH  - Sensitivity and Specificity
MH  - Sensory Thresholds/physiology
MH  - *Signal Processing, Computer-Assisted
MH  - Synaptic Transmission/*physiology
MH  - Time Factors
PMC - PMC6762847
EDAT- 2001/07/05 10:00
MHDA- 2001/07/28 10:01
PMCR- 2002/01/15
CRDT- 2001/07/05 10:00
PHST- 2001/07/05 10:00 [pubmed]
PHST- 2001/07/28 10:01 [medline]
PHST- 2001/07/05 10:00 [entrez]
PHST- 2002/01/15 00:00 [pmc-release]
AID - 21/14/5328 [pii]
AID - 5414 [pii]
AID - 10.1523/JNEUROSCI.21-14-05328.2001 [doi]
PST - ppublish
SO  - J Neurosci. 2001 Jul 15;21(14):5328-43. doi: 10.1523/JNEUROSCI.21-14-05328.2001.