PMID- 11438942
OWN - NLM
STAT- MEDLINE
DCOM- 20010830
LR  - 20161124
IS  - 0022-3034 (Print)
IS  - 0022-3034 (Linking)
VI  - 48
IP  - 2
DP  - 2001 Aug
TI  - Neurotrophins, but not depolarization, regulate substance P expression in the 
      developing optic tectum.
PG  - 131-49
AB  - Neurotransmitter expression can be regulated by both activity and neurotrophins 
      in a number of in vitro systems. We examined whether either of these factors was 
      likely to play a role in the in vivo optic nerve-dependent regulation of a 
      substance P-like immunoreactive (SP-ir) population of cells in the developing 
      optic tectum of the frog. In contrast to our previous results with the adult 
      system, blocking tectal cell responses to glutamate release by retinal ganglion 
      cells with 6-cyano-7-nitroquinoxaline-2,3 dione (CNQX) did not affect the percent 
      of SP-ir cells in the developing tectum. Treatment with 
      d-(-)-2-amino-5-phosphonovaleric acid (d-AP-5) was also ineffective in this 
      regard, although both it and CNQX treatment disrupted visual map topography. 
      Chronic treatment with brain-derived neurotrophic factor (BDNF) and 
      neurotrophin-4/5 (NT-4/5) produced increases in SP-ir cells in the treated lobes 
      of normal animals, which were significant in the case of NT-4/5. Both substances 
      also prevented the decrease of SP cells that would otherwise occur in the 
      deafferented lobe of unilaterally optic nerve-transected tadpoles. These changes 
      in the percent of SP-ir cells occurred without any detectable changes in the 
      overall number of tectal cells. NGF had no effect on SP expression. Nor did it 
      affect topographic map formation, which was disrupted by treatment with either 
      BDNF or NT-4/5. Our results demonstrate that different mechanisms regulate SP 
      expression in the developing and adult tectum. They indicate that neurotrophin 
      levels in the developing optic tectum may selectively regulate a specific 
      neuropeptide-expressing population of cells.
CI  - Copyright 2001 John Wiley & Sons, Inc.
FAU - Tu, S
AU  - Tu S
AD  - School of Biological Sciences, University of Kentucky, Lexington, Kentucky 40506, 
      USA.
FAU - Debski, E A
AU  - Debski EA
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Neurobiol
JT  - Journal of neurobiology
JID - 0213640
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 145172-44-7 (neurotrophin 5)
RN  - 33507-63-0 (Substance P)
RN  - 6OTE87SCCW (6-Cyano-7-nitroquinoxaline-2,3-dione)
RN  - 76726-92-6 (2-Amino-5-phosphonovalerate)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - 2-Amino-5-phosphonovalerate/pharmacology
MH  - 6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacology
MH  - Animals
MH  - Brain Mapping
MH  - Brain-Derived Neurotrophic Factor/pharmacology
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Female
MH  - Male
MH  - Membrane Potentials/physiology
MH  - Nerve Growth Factors/*pharmacology
MH  - Neuronal Plasticity/drug effects/physiology
MH  - Neuroprotective Agents/pharmacology
MH  - Rana pipiens
MH  - Receptors, N-Methyl-D-Aspartate/physiology
MH  - Retinal Ganglion Cells/drug effects/metabolism
MH  - Substance P/analysis/*biosynthesis
MH  - Superior Colliculi/drug effects/*growth & development/*metabolism
MH  - Visual Pathways/drug effects/growth & development/metabolism
EDAT- 2001/07/05 10:00
MHDA- 2001/08/31 10:01
CRDT- 2001/07/05 10:00
PHST- 2001/07/05 10:00 [pubmed]
PHST- 2001/08/31 10:01 [medline]
PHST- 2001/07/05 10:00 [entrez]
AID - 10.1002/neu.1047 [pii]
PST - ppublish
SO  - J Neurobiol. 2001 Aug;48(2):131-49.