PMID- 11438955
OWN - NLM
STAT- MEDLINE
DCOM- 20010913
LR  - 20041117
IS  - 0197-3851 (Print)
IS  - 0197-3851 (Linking)
VI  - 21
IP  - 6
DP  - 2001 Jun
TI  - Prenatal diagnosis of two rare de novo structural aberrations of the Y 
      chromosome: cytogenetic and molecular analysis.
PG  - 484-7
AB  - Two rare de novo structural aberrations of the Y chromosome were detected during 
      routine prenatal diagnosis: a satellited non-fluorescent Y chromosome (Yqs), the 
      first de novo Yqs to be reported in a fetus, and a terminal deletion of the Y 
      chromosome long arm del(Y)(q11). In both cases detailed cytogenetic and molecular 
      analyses were undertaken. In the case of the Yqs it was demonstrated by 
      fluorescence in situ hybridization (FISH) that the satellites were derived from 
      chromosome 15. In the case of the del(Yq), it was shown with molecular analysis 
      by polymerase chain reaction (PCR) amplification of sequence-tagged sites 
      (STS-PCR) that the deleted portion of the long arm of chromosome Y included the 
      azoospermia factor loci, AZFb and AZFc. The clinical significance of these 
      findings is discussed.
FAU - Velissariou, V
AU  - Velissariou V
AD  - Cytogenetics Laboratory, Department of Genetics and Molecular Biology, Mitera 
      Maternity and Surgical Center, Athens, Greece.
FAU - Antoniadi, T
AU  - Antoniadi T
FAU - Patsalis, P
AU  - Patsalis P
FAU - Christopoulou, S
AU  - Christopoulou S
FAU - Hatzipouliou, A
AU  - Hatzipouliou A
FAU - Donoghue, J
AU  - Donoghue J
FAU - Bakou, K
AU  - Bakou K
FAU - Kaminopetros, P
AU  - Kaminopetros P
FAU - Athanassiou, V
AU  - Athanassiou V
FAU - Petersen, M B
AU  - Petersen MB
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Prenat Diagn
JT  - Prenatal diagnosis
JID - 8106540
SB  - IM
MH  - Adult
MH  - Chromosome Deletion
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Pregnancy
MH  - Pregnancy Trimester, First
MH  - *Prenatal Diagnosis
MH  - Sex Chromosome Aberrations/*diagnosis/genetics
MH  - *Y Chromosome
EDAT- 2001/07/05 10:00
MHDA- 2001/09/14 10:01
CRDT- 2001/07/05 10:00
PHST- 2001/07/05 10:00 [pubmed]
PHST- 2001/09/14 10:01 [medline]
PHST- 2001/07/05 10:00 [entrez]
AID - 10.1002/pd.79 [doi]
PST - ppublish
SO  - Prenat Diagn. 2001 Jun;21(6):484-7. doi: 10.1002/pd.79.