PMID- 11439160
OWN - NLM
STAT- MEDLINE
DCOM- 20010809
LR  - 20190818
IS  - 0300-9475 (Print)
IS  - 0300-9475 (Linking)
VI  - 54
IP  - 1-2
DP  - 2001 Jul-Aug
TI  - Structure and chromosomal localization of chicken CD5.
PG  - 141-5
AB  - CD5 is a transmembrane glycoprotein on all T cells and on a subpopulation of B 
      cells. Based on the analysis of chicken CD5-cDNA we have previously shown that 
      the structure of the CD5 protein is conserved between species. Here we report the 
      isolation and chromosomal mapping of the chicken CD5 gene. The gene spans 3.4 kb 
      and is extremely compact with a high GC-nucleotide content. There are 10 exons 
      and the introns are spliced out similarly to those in the human CD5 gene. Each of 
      the three extracellular scavenger receptor cysteine-rich (SRCR) domains is 
      encoded as an exon of its own, as is the proline-rich hinge region that separates 
      the first two membrane-distal SRCR domains. The fluorescence in situ 
      hybridization (FISH) technique was used to map the gene to chromosome five. This 
      is the first report describing the organization of the CD5 gene from a 
      nonmammalian species.
FAU - Koskinen, R
AU  - Koskinen R
AD  - Turku Immunology Centre and Department of Medical Microbiology, Turku University, 
      Turku, Finland.
FAU - Salomonsen, J
AU  - Salomonsen J
FAU - Goodchild, M
AU  - Goodchild M
FAU - Bumstead, N
AU  - Bumstead N
FAU - Boyd, Y
AU  - Boyd Y
FAU - Vainio, O
AU  - Vainio O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Scand J Immunol
JT  - Scandinavian journal of immunology
JID - 0323767
RN  - 0 (CD5 Antigens)
RN  - 0 (Membrane Glycoproteins)
SB  - IM
MH  - Animals
MH  - CD5 Antigens/*genetics
MH  - Chickens/*genetics/immunology
MH  - Chromosome Mapping
MH  - Membrane Glycoproteins/*genetics
EDAT- 2001/07/06 10:00
MHDA- 2001/08/10 10:01
CRDT- 2001/07/06 10:00
PHST- 2001/07/06 10:00 [pubmed]
PHST- 2001/08/10 10:01 [medline]
PHST- 2001/07/06 10:00 [entrez]
AID - sji961 [pii]
AID - 10.1046/j.1365-3083.2001.00961.x [doi]
PST - ppublish
SO  - Scand J Immunol. 2001 Jul-Aug;54(1-2):141-5. doi: 
      10.1046/j.1365-3083.2001.00961.x.