PMID- 11440086
OWN - NLM
STAT- MEDLINE
DCOM- 20011204
LR  - 20190915
IS  - 0253-6269 (Print)
IS  - 0253-6269 (Linking)
VI  - 24
IP  - 3
DP  - 2001 Jun
TI  - Antiallergic action of Magnolia officinalis on immediate hypersensitivity 
      reaction.
PG  - 249-55
AB  - We studied the effect of aqueous extract of Magnolia officinalis bark 
      (Magnoliaceae) (MOAE) on the immediate hypersensitivity reaction. MOAE (0.01 to 1 
      g/kg) dose-dependently inhibited compound 48/80 induced systemic anaphylaxis in 
      rats. MOAE (0.1 and 1 g/kg) also significantly inhibited local immunoglobulin E 
      (IgE)-mediated passive cutaneous anaphylactic reaction. When MOAE was pretreated 
      at concentrations ranging from 0.01 to 1 g/kg, the levels of plasma histamine 
      were reduced in a dose-dependent manner. MOAE (0.001 to 1 mg/ml) dose-dependently 
      inhibited the histamine release from rat peritoneal mast cells (RPMC) activated 
      by compound 48/80 or anti-dinitrophenyl (DNP) IgE. The level of cyclic AMP (cAMP) 
      in RPMC, when MOAE was added, significantly increased compared with that of the 
      normal control. Moreover, MOAE (0.01 to 1 mg/ml) had a significant inhibitory 
      effect on anti-DNP IgE-induced tumor necrosis factor-alpha production from RPMC. 
      These results indicate that MOAE inhibits immediate hypersensitivity reaction in 
      vivo and in vitro.
FAU - Shin, T Y
AU  - Shin TY
AD  - College of Pharmacy, Woosuk University, Chonju, Chonbuk, Korea. 
      tyshin@core.woosuk.ac.kr
FAU - Kim, D K
AU  - Kim DK
FAU - Chae, B S
AU  - Chae BS
FAU - Lee, E J
AU  - Lee EJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Korea (South)
TA  - Arch Pharm Res
JT  - Archives of pharmacal research
JID - 8000036
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Indicators and Reagents)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - E0399OZS9N (Cyclic AMP)
SB  - IM
MH  - Animals
MH  - Anti-Allergic Agents/*therapeutic use
MH  - Cyclic AMP/biosynthesis
MH  - Histamine Release/drug effects
MH  - Hypersensitivity, Immediate/*drug therapy
MH  - Indicators and Reagents
MH  - Male
MH  - Mast Cells/drug effects/metabolism
MH  - Passive Cutaneous Anaphylaxis/drug effects
MH  - *Phytotherapy
MH  - Plant Extracts/*therapeutic use
MH  - Plants, Medicinal/*chemistry
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tumor Necrosis Factor-alpha/biosynthesis
MH  - p-Methoxy-N-methylphenethylamine/antagonists & inhibitors/pharmacology
EDAT- 2001/07/07 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/07/07 10:00
PHST- 2001/07/07 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/07/07 10:00 [entrez]
AID - 10.1007/BF02978266 [doi]
PST - ppublish
SO  - Arch Pharm Res. 2001 Jun;24(3):249-55. doi: 10.1007/BF02978266.