PMID- 11441342
OWN - NLM
STAT- MEDLINE
DCOM- 20010913
LR  - 20211203
IS  - 1093-5266 (Print)
IS  - 1093-5266 (Linking)
VI  - 4
IP  - 4
DP  - 2001 Jul-Aug
TI  - Neutrophil-rich anaplastic large cell lymphoma of the skull presenting after head 
      trauma.
PG  - 397-401
AB  - The presentation of anaplastic large cell lymphoma in bone is uncommon. We report 
      a case of anaplastic large cell lymphoma of the skull that was diagnosed after 
      head trauma. Biopsy revealed significant destruction of the outer table of the 
      frontal bone. Histopathologically, the initial evaluation suggested osteomyelitis 
      because of a mixed inflammatory infiltrate with large numbers of neutrophils. 
      However, several clusters and individual mononuclear cells were atypical. The 
      tumor cells had large, pleomorphic nuclei; these cells stained positively with 
      antibodies to Ki-1 (CD 30), ALK-1, and EMA. Fluorescence in situ hybridization 
      (FISH) showed rearrangement of the ALK gene, which usually results from the 
      t(2;5) translocation, present in most anaplastic large cell lymphomas. There was 
      no evidence of systemic disease. The patient has tolerated chemotherapy and is 
      free of disease 12 months later.
FAU - Parker, J R
AU  - Parker JR
AD  - Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, 
      TX 77030, USA.
FAU - Lopez-Terrada, D
AU  - Lopez-Terrada D
FAU - Gresik, M V
AU  - Gresik MV
FAU - Vogel, H
AU  - Vogel H
FAU - Baumgartner, J E
AU  - Baumgartner JE
FAU - Finegold, M J
AU  - Finegold MJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Pediatr Dev Pathol
JT  - Pediatric and developmental pathology : the official journal of the Society for 
      Pediatric Pathology and the Paediatric Pathology Society
JID - 9809673
RN  - 0 (DNA, Neoplasm)
RN  - 0 (E2F6 Transcription Factor)
RN  - 0 (E2F6 protein, human)
RN  - 0 (Ki-1 Antigen)
RN  - 0 (Repressor Proteins)
RN  - 0 (Transcription Factors)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.30 (Activin Receptors)
SB  - IM
MH  - Activin Receptors
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Cell Nucleus/chemistry/genetics/pathology
MH  - Child
MH  - *Craniocerebral Trauma
MH  - DNA, Neoplasm/analysis
MH  - E2F6 Transcription Factor
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - *Ki-1 Antigen/analysis
MH  - Lymphoma, Large-Cell, Anaplastic/chemistry/drug therapy/genetics/*pathology
MH  - Male
MH  - Neutrophils/*pathology
MH  - Protein Serine-Threonine Kinases/analysis/genetics
MH  - Repressor Proteins/analysis
MH  - Skull Neoplasms/chemistry/drug therapy/genetics/*pathology
MH  - Transcription Factors/analysis
EDAT- 2001/07/07 10:00
MHDA- 2001/09/14 10:01
CRDT- 2001/07/07 10:00
PHST- 2000/04/24 00:00 [received]
PHST- 2000/10/25 00:00 [accepted]
PHST- 2001/07/07 10:00 [pubmed]
PHST- 2001/09/14 10:01 [medline]
PHST- 2001/07/07 10:00 [entrez]
AID - 10.1007/s10024001-0004-7 [doi]
PST - ppublish
SO  - Pediatr Dev Pathol. 2001 Jul-Aug;4(4):397-401. doi: 10.1007/s10024001-0004-7.