PMID- 11442213
OWN - NLM
STAT- MEDLINE
DCOM- 20010726
LR  - 20190605
IS  - 0002-9637 (Print)
IS  - 0002-9637 (Linking)
VI  - 64
IP  - 3-4
DP  - 2001 Mar-Apr
TI  - Randomized intervention study comparing several regimens for the treatment of 
      moderate anemia among refugee children in Kigoma Region, Tanzania.
PG  - 164-71
AB  - Anemia-specific mortality was markedly elevated among refugee children < 5 years 
      of age in Tanzania. In a randomized, double-blind study, 215 anemic children were 
      initially treated for malaria and helminth infection and then received 12 weeks 
      of thrice-weekly oral iron and folic acid. Group I received placebo and 
      chloroquine treatment for symptomatic malaria infection (i.e., no presumptive 
      anti-malarial treatment given). Group II received placebo and monthly presumptive 
      treatment with sulfamethoxazole-pyrimethamine (SP). Group III also received 
      monthly SP and thrice-weekly vitamins A and C (VAC). Mean hemoglobin 
      concentration increased from 6.6 to 10.2 g/dL, with no significant differences 
      among groups. Group II had lower mean serum transferrin receptor levels (TfR) 
      than group I [P = 0.023]. A greater proportion of participants in group III had 
      normal iron stores (TfR < 8.5 microg/ mL) than in group II [P = 0.012]. Initial 
      helminth and malaria treatment, followed by thrice-weekly iron and folic acid 
      supplements resulted in increased hemoglobin levels. Monthly SP and thrice-weekly 
      VAC contributed to improve iron stores. Monthly SP may have a role in situations 
      where asymptomatic disease is prevalent or where access to care is limited. 
      Because administration of VAC also hastened recovery of iron stores over 
      administration of monthly SP alone, health care personnel could add VAC to the 
      treatment for moderate anemia if maximum recovery of iron stores is desired.
FAU - Tomashek, K M
AU  - Tomashek KM
AD  - International Emergency and Refugee Health Branch, Centers for Disease Control 
      and Prevention, Atlanta, Georgia 30341, USA.
FAU - Woodruff, B A
AU  - Woodruff BA
FAU - Gotway, C A
AU  - Gotway CA
FAU - Bloland, P
AU  - Bloland P
FAU - Mbaruku, G
AU  - Mbaruku G
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
RN  - 0 (Antimalarials)
RN  - 0 (Iron, Dietary)
RN  - 11103-57-4 (Vitamin A)
RN  - 886U3H6UFF (Chloroquine)
RN  - 935E97BOY8 (Folic Acid)
RN  - JE42381TNV (Sulfamethoxazole)
RN  - PQ6CK8PD0R (Ascorbic Acid)
RN  - Z3614QOX8W (Pyrimethamine)
SB  - IM
MH  - Anemia, Iron-Deficiency/*drug therapy
MH  - Antimalarials/*therapeutic use
MH  - Ascorbic Acid/administration & dosage
MH  - Child, Preschool
MH  - Chloroquine/*therapeutic use
MH  - Double-Blind Method
MH  - Drug Administration Schedule
MH  - Female
MH  - Folic Acid/administration & dosage
MH  - Humans
MH  - Infant
MH  - Iron, Dietary/administration & dosage
MH  - Malaria/*drug therapy
MH  - Male
MH  - Pyrimethamine/*therapeutic use
MH  - Refugees
MH  - Severity of Illness Index
MH  - Sulfamethoxazole/*therapeutic use
MH  - Tanzania
MH  - Vitamin A/administration & dosage
EDAT- 2001/07/10 10:00
MHDA- 2001/07/28 10:01
CRDT- 2001/07/10 10:00
PHST- 2001/07/10 10:00 [pubmed]
PHST- 2001/07/28 10:01 [medline]
PHST- 2001/07/10 10:00 [entrez]
AID - 10.4269/ajtmh.2001.64.164 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 2001 Mar-Apr;64(3-4):164-71. doi: 10.4269/ajtmh.2001.64.164.