PMID- 11443137
OWN - NLM
STAT- MEDLINE
DCOM- 20011011
LR  - 20210209
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 276
IP  - 36
DP  - 2001 Sep 7
TI  - Tumor necrosis factor-alpha-induced adipose-related protein (TIARP), a 
      cell-surface protein that is highly induced by tumor necrosis factor-alpha and 
      adipose conversion.
PG  - 33938-46
AB  - Tumor necrosis factor-alpha (TNF alpha) is involved in the physiological and 
      biological abnormalities found in two opposite metabolic situations: cachexia and 
      obesity. In an attempt to identify novel genes and proteins that could mediate 
      the effects of TNFalpha on adipocyte metabolism and development, we have used a 
      differential display technique comparing 3T3-L1 cells exposed or not to the 
      cytokine. We have isolated a novel adipose cDNA encoding a TNF alpha-inducible 
      470-amino acid protein termed TIARP, with six putative transmembrane regions 
      flanked by a large amino-terminal and a short carboxyl-terminal domain, a 
      structure reminiscent of channel and transporter proteins. Commitment into the 
      differentiation process is required for cytokine responsiveness. The 
      differentiation process per se is accompanied by a sharp emergence of TIARP mRNA 
      transcripts, in parallel with the expression of the protein at the plasma 
      membrane. Transcripts are present at high levels in white and brown adipose 
      tissues, and are also detectable in liver, kidney, heart, and skeletal muscle. 
      Whereas the biological function of TIARP is presently unknown, its pattern of 
      expression during adipose conversion and in response to TNF alpha exposure as a 
      transmembrane protein mainly located at the cell surface suggest that TIARP might 
      participate in adipocyte development and metabolism and mediate some TNF alpha 
      effects on the fat cell as a channel or a transporter.
FAU - Moldes, M
AU  - Moldes M
AD  - UMR 7079 CNRS, Universite Pierre et Marie Curie, Centre de Recherche Biomedicale 
      des Cordeliers, 15 rue de l'Ecole de Medecine, 75270 Paris Cedex 06, France.
FAU - Lasnier, F
AU  - Lasnier F
FAU - Gauthereau, X
AU  - Gauthereau X
FAU - Klein, C
AU  - Klein C
FAU - Pairault, J
AU  - Pairault J
FAU - Feve, B
AU  - Feve B
FAU - Chambaut-Guerin, A M
AU  - Chambaut-Guerin AM
LA  - eng
SI  - GENBANK/AJ319746
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20010706
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Amino Acids)
RN  - 0 (DNA, Complementary)
RN  - 0 (Membrane Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tiarp protein, mouse)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - 3T3 Cells
MH  - Adipocytes/*metabolism
MH  - Adipose Tissue/*metabolism
MH  - Amino Acid Sequence
MH  - Amino Acids/chemistry
MH  - Animals
MH  - Blotting, Northern
MH  - Blotting, Western
MH  - Cell Differentiation
MH  - Cell Line
MH  - Cell Membrane/chemistry/metabolism
MH  - DNA, Complementary/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Gene Expression Profiling
MH  - Gene Library
MH  - Immunohistochemistry
MH  - Membrane Proteins/*chemistry/*physiology
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Microscopy, Fluorescence
MH  - Molecular Sequence Data
MH  - Obesity/metabolism
MH  - Protein Binding
MH  - Protein Biosynthesis
MH  - Protein Structure, Tertiary
MH  - RNA, Messenger/metabolism
MH  - Sequence Homology, Amino Acid
MH  - Time Factors
MH  - Tissue Distribution
MH  - Transcription, Genetic
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 2001/07/10 10:00
MHDA- 2001/10/12 10:01
CRDT- 2001/07/10 10:00
PHST- 2001/07/10 10:00 [pubmed]
PHST- 2001/10/12 10:01 [medline]
PHST- 2001/07/10 10:00 [entrez]
AID - S0021-9258(19)34798-2 [pii]
AID - 10.1074/jbc.M105726200 [doi]
PST - ppublish
SO  - J Biol Chem. 2001 Sep 7;276(36):33938-46. doi: 10.1074/jbc.M105726200. Epub 2001 
      Jul 6.