PMID- 11443536
OWN - NLM
STAT- MEDLINE
DCOM- 20010906
LR  - 20131121
IS  - 1359-4184 (Print)
IS  - 1359-4184 (Linking)
VI  - 6
IP  - 4
DP  - 2001 Jul
TI  - Brain-derived-neurotrophic-factor (BDNF) stress response in rats bred for learned 
      helplessness.
PG  - 471-4, 358
AB  - Stress-induced elevation of glucocorticoids is accompanied by structural changes 
      and neuronal damage in certain brain areas. This includes reduced expression of 
      brain-derived neurotrophic factor (BDNF) in the hippocampus which can be 
      prevented by chronic electroconvulsive seizures and antidepressant drug 
      treatment. In the last years we have bred two strains of rats, one which reacts 
      with congenital helplessness to stress (cLH), and one which congenitally does not 
      acquire helplessness when stressed (cNLH). After being selectively bred for more 
      than 40 generations these strains have lost their behavioural plasticity 
      including their sensitivity to antidepressant treatment. We show here that in cLH 
      rats, acute immobilization stress does not induce a reduction of BDNF expression 
      in the hippocampus which is observed in Sprague--Dawley and cNLH rats. All 
      animals tested exhibited elevated corticosterone levels when stressed, an 
      indication, that in cLH rats regulation of BDNF expression in the hippocampal 
      formation is uncoupled from corticosterone increase induced through stress. This 
      may explain the lack of adaptive responses in this strain.
FAU - Vollmayr, B
AU  - Vollmayr B
AD  - Central Institute of Mental Health, J5, D-68159 Mannheim, Germany.
FAU - Faust, H
AU  - Faust H
FAU - Lewicka, S
AU  - Lewicka S
FAU - Henn, F A
AU  - Henn FA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Mol Psychiatry
JT  - Molecular psychiatry
JID - 9607835
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Corticosterone/blood
MH  - Electroshock
MH  - Escape Reaction
MH  - *Gene Expression Regulation
MH  - *Helplessness, Learned
MH  - In Situ Hybridization
MH  - Inbreeding
MH  - RNA, Messenger/genetics
MH  - Rats
MH  - Rats, Mutant Strains
MH  - Rats, Sprague-Dawley
MH  - Stress, Psychological/blood/genetics
MH  - *Transcription, Genetic
EDAT- 2001/07/10 10:00
MHDA- 2001/09/08 10:01
CRDT- 2001/07/10 10:00
PHST- 2000/03/21 00:00 [received]
PHST- 2001/02/16 00:00 [revised]
PHST- 2001/02/20 00:00 [accepted]
PHST- 2001/07/10 10:00 [pubmed]
PHST- 2001/09/08 10:01 [medline]
PHST- 2001/07/10 10:00 [entrez]
AID - 10.1038/sj.mp.4000907 [doi]
PST - ppublish
SO  - Mol Psychiatry. 2001 Jul;6(4):471-4, 358. doi: 10.1038/sj.mp.4000907.