PMID- 11443638
OWN - NLM
STAT- MEDLINE
DCOM- 20010809
LR  - 20041117
IS  - 0361-8609 (Print)
IS  - 0361-8609 (Linking)
VI  - 67
IP  - 4
DP  - 2001 Aug
TI  - Successful treatment of severe aplastic anemia associated with human parvovirus 
      B19 and Epstein-Barr virus in a healthy subject with allo-BMT.
PG  - 252-5
AB  - Several reports have noted pancytopenia associated with Human parvovirus B19 
      (PVB19) or Ebstein-Barr virus (EBV) infections in patients who have no history of 
      immunodeficiency. To our knowledge, we report the first case of severe aplastic 
      anemia associated with both EBV and PVB19 infections in a previously healthy 
      22-year-old man. He was admitted to our hematology service due to anemia and 
      thrombocytopenia. He had no symptoms or signs of infections of these viruses. His 
      bone marrow biopsy revealed a hypocellular marrow. Specific IgM and IgG 
      antibodies to EBV and PVB19 were elevated. EBV and PVB19 virus genomes were 
      detected by PCR in the bone marrow nucleated cells and the peripheral blood 
      lymphocytes. Two months after treatment with prednisone, acyclovir, and 
      intravenous immune globulin (IVIg), the genomes of both these viruses 
      disappeared. However, his transfusion requirement for platelet suspensions and 
      packed red blood cells persisted. The patient underwent allogeneic bone marrow 
      transplant (allo-BMT) and has had an enduring complete hematological response for 
      8 months.
FAU - Kaptan, K
AU  - Kaptan K
AD  - Hematology Department, Gulhane Military Medical Academy, Etlik, Ankara, Turkey. 
      kkaptan@gata.edu.tr
FAU - Beyan, C
AU  - Beyan C
FAU - Ural, A U
AU  - Ural AU
FAU - Ustun, C
AU  - Ustun C
FAU - Cetin, T
AU  - Cetin T
FAU - Avcu, F
AU  - Avcu F
FAU - Kubar, A
AU  - Kubar A
FAU - Alis, M
AU  - Alis M
FAU - Yalcin, A
AU  - Yalcin A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am J Hematol
JT  - American journal of hematology
JID - 7610369
SB  - IM
MH  - Adult
MH  - Anemia, Aplastic/etiology/therapy/*virology
MH  - Bone Marrow/pathology/virology
MH  - *Bone Marrow Transplantation
MH  - Epstein-Barr Virus Infections/*complications/drug therapy
MH  - Humans
MH  - Male
MH  - Parvoviridae Infections/*complications/drug therapy
MH  - Platelet Transfusion
MH  - Transplantation, Homologous
MH  - Treatment Outcome
EDAT- 2001/07/10 10:00
MHDA- 2001/08/10 10:01
CRDT- 2001/07/10 10:00
PHST- 2001/07/10 10:00 [pubmed]
PHST- 2001/08/10 10:01 [medline]
PHST- 2001/07/10 10:00 [entrez]
AID - 10.1002/ajh.1125 [doi]
PST - ppublish
SO  - Am J Hematol. 2001 Aug;67(4):252-5. doi: 10.1002/ajh.1125.