PMID- 11445829
OWN - NLM
STAT- MEDLINE
DCOM- 20011207
LR  - 20220321
IS  - 0958-0670 (Print)
IS  - 0958-0670 (Linking)
VI  - 86
IP  - 4
DP  - 2001 Jul
TI  - Interaction of diet and training on endurance performance in rats.
PG  - 499-508
AB  - We determined the interaction of diet and training on metabolic adaptations in 
      skeletal muscle and liver, and the consequences of these adaptations for 
      endurance. Eighty rats performed a baseline treadmill run to exhaustion at 16 m 
      min(-1) (RUN1) and were then divided into two groups and given one of two diets: 
      high carbohydrate (CHO) or high fat (FAT). Each dietary group was then divided 
      into one of four subgroups: sedentary control that performed no training (NT); 
      low-intensity running (8 m min(-1); LOW) and two groups who trained at their 
      maximal voluntary running speed without electrical stimulation (28 m min(-1); 
      VMAX). Training volume was identical for LOW and VMAX (1000 m session(-1)) and 
      animals ran 4 days week(-1) for 8 weeks. To assess the interaction of the higher 
      intensity exercise with diet, a second endurance test (RUN2) was undertaken after 
      6 weeks at either 16 m min(-1) or 28 m min(-1). The NT group ran for a longer 
      duration (increase of 77 %) after FAT than CHO (239 +/- 28 vs. 135 +/- 30 min, P 
      < 0.05) at 16 m min(-1). There were no differences in RUN2 for the LOW group when 
      rats ran at 16 m min(-1) (454 +/- 86 vs. 427 +/- 75 min for CHO and FAT groups, 
      respectively), but rats in the VMAX group fed FAT ran longer than rats fed CHO at 
      28 m min(-1) (100 +/- 28 vs. 58 +/- 11 min, respectively, P < 0.05). FAT 
      increased the activities of the enzymes citrate synthase, beta-hydroxyacyl-CoA 
      dehydrogenase and carnitine palmitoyl-transferase compared to CHO (P < 0.01), but 
      there was no systematic effect of training. We conclude: (1) there was no 
      additive effect of a high-fat diet on endurance performance when rats performed 
      low-intensity training; (2) running performance at 28 m min(-1) was only enhanced 
      by a high-fat diet after more intense training; (3) diet-induced and 
      training-induced adaptations that increase exercise capacity may be under 
      independent control. Experimental Physiology (2001) 86.4, 499-508.
FAU - Lee, J S
AU  - Lee JS
AD  - Exercise Metabolism Group, School of Medical Sciences, RMIT University, Bundoora 
      3083, Victoria, Australia.
FAU - Bruce, C R
AU  - Bruce CR
FAU - Spriet, L L
AU  - Spriet LL
FAU - Hawley, J A
AU  - Hawley JA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Exp Physiol
JT  - Experimental physiology
JID - 9002940
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 9005-79-2 (Glycogen)
RN  - EC 1.1.1.- (3-Hydroxyacyl CoA Dehydrogenases)
RN  - EC 2.3.1.21 (Carnitine O-Palmitoyltransferase)
RN  - EC 2.3.3.1 (Citrate (si)-Synthase)
SB  - IM
MH  - 3-Hydroxyacyl CoA Dehydrogenases/metabolism
MH  - Animals
MH  - Blood Glucose
MH  - Body Mass Index
MH  - Carnitine O-Palmitoyltransferase/metabolism
MH  - Citrate (si)-Synthase/metabolism
MH  - Diet
MH  - Dietary Carbohydrates/*pharmacology
MH  - Dietary Fats/*pharmacology
MH  - Drinking/physiology
MH  - Energy Metabolism/physiology
MH  - Female
MH  - Glycogen/metabolism
MH  - Liver/metabolism
MH  - Muscle, Skeletal/enzymology
MH  - Physical Conditioning, Animal/*physiology
MH  - Physical Endurance/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2001/07/11 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/07/11 10:00
PHST- 2001/07/11 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/07/11 10:00 [entrez]
AID - EPH_2158 [pii]
AID - 10.1113/eph8602158 [doi]
PST - ppublish
SO  - Exp Physiol. 2001 Jul;86(4):499-508. doi: 10.1113/eph8602158.