PMID- 11446432
OWN - NLM
STAT- MEDLINE
DCOM- 20010809
LR  - 20191105
IS  - 0018-7143 (Print)
IS  - 0018-7143 (Linking)
VI  - 73
IP  - 2
DP  - 2001 Apr
TI  - Paternal HLA genotype and offspring sex ratio.
PG  - 315-9
AB  - For twenty years, W.H. James has been proposing that the sex hormone level of 
      both parents could control at least a quota of the secondary sex ratio variation 
      at the time of conception. Observations supporting this hypothesis have come from 
      investigations on some diseases related to the human leukocyte antigen (HLA). In 
      the present study on 1102 healthy Italian families, we investigated the potential 
      effect on the offspring sex ratio of HLA-B alleles on the basis of a genetic 
      model. We defined three subsets of HLA-B alleles and hypothesized a locus (L) 
      with three alleles, L(H), L(N), L(B15), on the basis of the positive, neutral, or 
      negative effect on the testosterone level. According to the genetic model and the 
      dominance relation L(H) > L(B15) > L(N), six genotypic and three phenotypic 
      classes (H, N, B15) can be expected. We found a significantly high number of 
      daughters (66%) born to fathers carrying the B15 phenotype. This result suggests 
      an effect of the HLA-B15 allele on the secondary sex ratio, mediated by a low 
      testosterone level.
FAU - Astolfi, P
AU  - Astolfi P
AD  - Department of Genetics and Microbiology, University of Pavia, Italy.
FAU - Cuccia, M
AU  - Cuccia M
FAU - Martinetti, M
AU  - Martinetti M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hum Biol
JT  - Human biology
JID - 0116717
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B15 Antigen)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Female
MH  - Genotype
MH  - HLA-B Antigens/*genetics
MH  - HLA-B15 Antigen
MH  - Humans
MH  - Italy/epidemiology
MH  - Male
MH  - Models, Genetic
MH  - Phenotype
MH  - *Sex Ratio
MH  - Testosterone/genetics/metabolism
EDAT- 2001/07/12 10:00
MHDA- 2001/08/10 10:01
CRDT- 2001/07/12 10:00
PHST- 2001/07/12 10:00 [pubmed]
PHST- 2001/08/10 10:01 [medline]
PHST- 2001/07/12 10:00 [entrez]
AID - 10.1353/hub.2001.0015 [doi]
PST - ppublish
SO  - Hum Biol. 2001 Apr;73(2):315-9. doi: 10.1353/hub.2001.0015.