PMID- 11446532
OWN - NLM
STAT- MEDLINE
DCOM- 20011207
LR  - 20190513
IS  - 1369-3786 (Print)
IS  - 1369-3786 (Linking)
VI  - 39
IP  - 3
DP  - 2001 Jun
TI  - Inhibition of hyphal growth of Candida albicans by activated lansoprazole, a 
      novel benzimidazole proton pump inhibitor.
PG  - 283-5
AB  - The effect of activated lansoprazole (AG 2000), a novel benzimidazole proton pump 
      inhibitor, against hypha formation of Candida albicans was examined in 
      hypha-forming medium pH 7 (HFM7) after 20 h. AG 2000, at 50-800 microM, did not 
      inhibit germ tube formation. However, it inhibited elongation of germ tubes to 
      form hyphae and favored conversion of germ tubes to resume yeast growth at 
      concentrations of > or =200 microM. Pre-treatment of AG 2000 with a sulfhydryl 
      reagent (1:1), such as 2-mercaptoethanol. blocked the inhibitory property of AG 
      2000 on hypha formation.
FAU - Biswas, S K
AU  - Biswas SK
AD  - Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 
      Japan.
FAU - Yokoyama, K
AU  - Yokoyama K
FAU - Kamei, K
AU  - Kamei K
FAU - Nishimura, K
AU  - Nishimura K
FAU - Miyaji, M
AU  - Miyaji M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Med Mycol
JT  - Medical mycology
JID - 9815835
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Antifungal Agents)
RN  - 0 (Benzimidazoles)
RN  - 0 (Culture Media)
RN  - 0 (Proton Pump Inhibitors)
RN  - 0K5C5T2QPG (Lansoprazole)
RN  - E24GX49LD8 (benzimidazole)
RN  - KG60484QX9 (Omeprazole)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles
MH  - Antifungal Agents/*pharmacology
MH  - Benzimidazoles/*pharmacology
MH  - Candida albicans/*drug effects/growth & development
MH  - Culture Media
MH  - Humans
MH  - Lansoprazole
MH  - Omeprazole/*analogs & derivatives/*pharmacology
MH  - *Proton Pump Inhibitors
EDAT- 2001/07/12 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/07/12 10:00
PHST- 2001/07/12 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/07/12 10:00 [entrez]
AID - 10.1080/mmy.39.3.283.285 [doi]
PST - ppublish
SO  - Med Mycol. 2001 Jun;39(3):283-5. doi: 10.1080/mmy.39.3.283.285.