PMID- 11448945
OWN - NLM
STAT- MEDLINE
DCOM- 20011018
LR  - 20210209
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 276
IP  - 35
DP  - 2001 Aug 31
TI  - Steroid hormone receptor-mediated histone deacetylation and transcription at the 
      mouse mammary tumor virus promoter.
PG  - 32423-6
AB  - Acetylation of lysines in histones H3 and H4 N-terminal tails is associated with 
      transcriptional activation and deacetylation with repression. Our studies with 
      the mouse mammary tumor virus (MMTV) promoter in chromatin show significant 
      levels of acetylation at promoter proximal and distal regions prior to 
      transactivation. Upon activation with glucocorticoids or progestins, promoter 
      proximal histones become deacetylated within the region of inducible nuclease 
      hypersensitivity. The deacetylation lags behind the initiation of transcription, 
      indicating a role in post-activation regulation. Our results indicate a novel 
      mechanism by which target promoters are regulated by steroid receptors and 
      chromatin modification machinery.
FAU - Sheldon, L A
AU  - Sheldon LA
AD  - Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, 
      USA. Lynn.A.Sheldon@dartmouth.edu
FAU - Becker, M
AU  - Becker M
FAU - Smith, C L
AU  - Smith CL
LA  - eng
GR  - DK03535/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20010711
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Chromatin)
RN  - 0 (Glucocorticoids)
RN  - 0 (Histones)
RN  - 0 (Progestins)
RN  - 0 (Receptors, Steroid)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - 9XE0V2SQYX (Promegestone)
SB  - IM
MH  - Adenocarcinoma
MH  - Animals
MH  - Cell Nucleus/metabolism
MH  - Chromatin/metabolism/ultrastructure
MH  - Dexamethasone/pharmacology
MH  - Glucocorticoids/pharmacology
MH  - Histones/*genetics/*metabolism
MH  - Kinetics
MH  - Mammary Tumor Virus, Mouse/*genetics
MH  - Mice
MH  - Progestins/pharmacology
MH  - Promegestone/pharmacology
MH  - *Promoter Regions, Genetic/drug effects
MH  - Receptors, Steroid/drug effects/*metabolism
MH  - Terminal Repeat Sequences
MH  - *Transcription, Genetic/drug effects
MH  - Tumor Cells, Cultured
EDAT- 2001/07/13 10:00
MHDA- 2001/10/19 10:01
CRDT- 2001/07/13 10:00
PHST- 2001/07/13 10:00 [pubmed]
PHST- 2001/10/19 10:01 [medline]
PHST- 2001/07/13 10:00 [entrez]
AID - S0021-9258(20)77758-6 [pii]
AID - 10.1074/jbc.C100315200 [doi]
PST - ppublish
SO  - J Biol Chem. 2001 Aug 31;276(35):32423-6. doi: 10.1074/jbc.C100315200. Epub 2001 
      Jul 11.