PMID- 11449801
OWN - NLM
STAT- MEDLINE
DCOM- 20010823
LR  - 20061115
IS  - 0208-0613 (Print)
IS  - 0208-0613 (Linking)
IP  - 2
DP  - 2001
TI  - [An antigen related to the mouse mammary cancer virus env gene product, detected 
      in human lymphocytes, is associated with human breast cancer].
PG  - 37-41
AB  - Expression of DNA sequences homologous to sequences of env gene of mouse mammary 
      tumor virus (MMTV) in the lymphocytes of patients with breast cancer and in 
      subjects at a high risk of breast cancer has been reported. Antigen analogous to 
      envelope protein gp52, product of MMTV env gene, is detected in T lymphocytes of 
      virtually all patients with breast cancer and extremely rarely in T cells of 
      controls, where its expression is confined to B cells. For explaining such 
      unexpected results, we studied the molecular basis of this antigen synthesis. 
      Specific PCR products were obtained using primers to gp52-coding region of MMTV 
      env gene. One of them (957 nucleotides) was used as a probe for hybridization of 
      DNA and RNA from lymphocytes of patients with breast cancer and controls. This 
      sequence was hybridized with 90% frequency with genome DNA of breast cancer 
      patients and with 85% frequency with genome RNA of such patients, which is almost 
      4-fold more than in the controls (patients with gynecological tumors or donors). 
      These results correlate with the frequency of detection of the studied antigen in 
      patients with breast cancer and control group patients.
FAU - Kriukova, I N
AU  - Kriukova IN
AD  - N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, 
      Moscow.
FAU - Lushnikova, A A
AU  - Lushnikova AA
FAU - Makhov, P B
AU  - Makhov PB
FAU - Malivanova, T F
AU  - Malivanova TF
FAU - Laktionov, K P
AU  - Laktionov KP
LA  - rus
PT  - English Abstract
PT  - Journal Article
TT  - Antigen, rodstvennyi produktu gena env virusa raka molochnykh zhelez myshei, 
      obnaruzhenny iv chelovecheskikh limfotsitakh, assotsirovan s rakom molochnyhkh 
      zhelez cheloveka.
PL  - Russia (Federation)
TA  - Mol Gen Mikrobiol Virusol
JT  - Molekuliarnaia genetika, mikrobiologiia i virusologiia
JID - 9315607
RN  - 0 (Antigens, Viral, Tumor)
RN  - 0 (DNA Primers)
RN  - 0 (RNA, Viral)
RN  - 0 (glycoprotein 52 antigen, Mouse mammary tumor virus)
SB  - IM
MH  - Antigens, Viral, Tumor/*genetics
MH  - Base Sequence
MH  - Blotting, Southern
MH  - Breast Neoplasms/*genetics
MH  - Case-Control Studies
MH  - DNA Primers
MH  - *Genes, Viral
MH  - *Genes, env
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Leukemia Virus, Murine/*genetics
MH  - Nucleic Acid Hybridization
MH  - Polymerase Chain Reaction
MH  - RNA, Viral/genetics
EDAT- 2001/07/14 10:00
MHDA- 2001/08/24 10:01
CRDT- 2001/07/14 10:00
PHST- 2001/07/14 10:00 [pubmed]
PHST- 2001/08/24 10:01 [medline]
PHST- 2001/07/14 10:00 [entrez]
PST - ppublish
SO  - Mol Gen Mikrobiol Virusol. 2001;(2):37-41.