PMID- 11450028
OWN - NLM
STAT- MEDLINE
DCOM- 20010809
LR  - 20190915
IS  - 0065-1419 (Print)
IS  - 0065-1419 (Linking)
VI  - 76
DP  - 2000
TI  - Neurotrophic factors attenuate alterations in spinal cord evoked potentials and 
      edema formation following trauma to the rat spinal cord.
PG  - 291-6
AB  - Influence of brain derived neurotrophic factor (BDNF) and insulin like growth 
      factor-1 (IGF-1) on spinal cord injury induced disturbances in spinal cord 
      conduction, edema formation and cellular stress response was examined in a rat 
      model. Pretreatment with BDNF or IGF-1 significantly attenuated the loss of SCEP 
      negative amplitude seen immediately after spinal cord injury. In these 
      neurotrophins treated rats, upregulation of heat shock protein (HSP 72 kD) 
      immunoreactivity, a measure of cellular stress response and spinal cord edema 
      formation were considerably reduced 5 h after injury. These results suggest that 
      neurotrophic factors improve spinal cord conduction after trauma and this 
      beneficial effect of growth factors may be related with their ability to 
      attenuate trauma induced cellular stress response, not reported earlier.
FAU - Winkler, T
AU  - Winkler T
AD  - Department of Clinical Neurophysiology, University Hospital, Uppsala, Sweden.
FAU - Sharma, H S
AU  - Sharma HS
FAU - Stalberg, E
AU  - Stalberg E
FAU - Badgaiyan, R D
AU  - Badgaiyan RD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Austria
TA  - Acta Neurochir Suppl
JT  - Acta neurochirurgica. Supplement
JID - 100962752
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Edema/*physiopathology
MH  - Evoked Potentials, Visual
MH  - Insulin-Like Growth Factor I/*pharmacology
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Spinal Cord/drug effects/physiopathology
MH  - Spinal Cord Injuries/*physiopathology
MH  - Synaptic Transmission/*drug effects/physiology
EDAT- 2001/07/14 10:00
MHDA- 2001/08/10 10:01
CRDT- 2001/07/14 10:00
PHST- 2001/07/14 10:00 [pubmed]
PHST- 2001/08/10 10:01 [medline]
PHST- 2001/07/14 10:00 [entrez]
AID - 10.1007/978-3-7091-6346-7_60 [doi]
PST - ppublish
SO  - Acta Neurochir Suppl. 2000;76:291-6. doi: 10.1007/978-3-7091-6346-7_60.