PMID- 11450038
OWN - NLM
STAT- MEDLINE
DCOM- 20010809
LR  - 20190915
IS  - 0065-1419 (Print)
IS  - 0065-1419 (Linking)
VI  - 76
DP  - 2000
TI  - Effects of inducible nitric oxide synthase inhibition on cerebral edema in severe 
      hypertension.
PG  - 335-8
AB  - In order to clarify the causative role of cytotoxic nitric oxide (NO) in 
      hypertensive cerebral injury, the effects of inducible nitric oxide synthase 
      (iNOS) inhibition on leukocytes and endothelial function were examined using 
      stroke-prone spontaneously hypertensive rats (SHRSP). For the iNOS inhibition, 
      S-methylisothiourea (SMT) was administered to 12-week-old male SHRSP for 3 weeks. 
      Immunohistochemical examination were carried out for the expression of 
      intercellular adhesion molecule-1 (ICAM-1), glucose transporter-1 (GLUT-1), 
      fibrinogen and glial fibrillary acidic protein (GFAP) in cerebral cortex. The 
      effects of iNOS inhibition was also examined for Mac-1 expression by flow 
      cytometric analysis. Plasma NO metabolites level was significantly lower in the 
      SMT group than in the control group. Mac-1 expression was inhibited by SMT. In 
      the SMT group, brain weight was significantly lower than in the control. By SMT 
      administration, ICAM-1 expression was suppressed, GLUT-1 was enhanced, fibrinogen 
      was decreased and GFAP was decreased as compared to those in control group. In 
      hypertensive cerebral injury in SHRSP, iNOS-derived NO, mainly in activated 
      leukocytes, could be an important causative factor for endothelial injury.
FAU - Takemori, K
AU  - Takemori K
AD  - Department of Pathology, Kinki University School of Medicine, Osaka, Japan.
FAU - Ito, H
AU  - Ito H
FAU - Suzuki, T
AU  - Suzuki T
LA  - eng
PT  - Journal Article
PL  - Austria
TA  - Acta Neurochir Suppl
JT  - Acta neurochirurgica. Supplement
JID - 100962752
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Monosaccharide Transport Proteins)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 22584-04-9 (Isothiuronium)
RN  - 9001-32-5 (Fibrinogen)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - ES8C3884JW (S-methylisothiopseudouronium)
SB  - IM
MH  - Animals
MH  - Brain Edema/*pathology
MH  - Cerebral Cortex/drug effects/pathology
MH  - Fibrinogen/metabolism
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Hypertension/*pathology
MH  - Intercellular Adhesion Molecule-1/metabolism
MH  - Isothiuronium/analogs & derivatives/*pharmacology
MH  - Male
MH  - Monosaccharide Transport Proteins/metabolism
MH  - Neutrophils/drug effects
MH  - Nitric Oxide Synthase/*antagonists & inhibitors/physiology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Stroke/*pathology
EDAT- 2001/07/14 10:00
MHDA- 2001/08/10 10:01
CRDT- 2001/07/14 10:00
PHST- 2001/07/14 10:00 [pubmed]
PHST- 2001/08/10 10:01 [medline]
PHST- 2001/07/14 10:00 [entrez]
AID - 10.1007/978-3-7091-6346-7_69 [doi]
PST - ppublish
SO  - Acta Neurochir Suppl. 2000;76:335-8. doi: 10.1007/978-3-7091-6346-7_69.