PMID- 11451617
OWN - NLM
STAT- MEDLINE
DCOM- 20010823
LR  - 20190915
IS  - 0378-5122 (Print)
IS  - 0378-5122 (Linking)
VI  - 39
IP  - 1
DP  - 2001 Jul 25
TI  - Early postmenopausal bone loss in hyperthyroidism.
PG  - 19-27
AB  - OBJECTIVES: To evaluate the effect of hyperthyroidism on bone in relation to the 
      menopausal state. METHODS: Fifty-nine hyperthyroid (HYPER), 40 hypothyroid 
      (HYPO), and 51 control euthyroid (EUTH) women were studied. Bone mineral density 
      (BMD) was assessed by dual X-rays absorptiometry (DXA) at the lumbar spine, and 
      at the femoral neck. A multi-site QUS device evaluated speed of sound (SOS) at 
      the radius (RAD), tibia (TIB), metatarsus (MTR), and phalanx (PLX). Bone markers 
      used were serum bone specific alkaline phosphatase (BSAP) and urinary 
      deoxypyridinoline (DPD). RESULTS: At all sites, SOS was lower in HYPER than in 
      EUTH (RAD P<0.05, TIB P<0.01, MTR P<0.05, PLX P=0.01). The low SOS was only noted 
      at the early postmenopausal period. BMD at the femoral neck but not at the lumbar 
      spine was lower in HYPER as compared to EUTH (P<0.05). Both femoral neck and 
      tibia were the sites with the highest odds ratio for being hyperthyroid (2.3 and 
      2.04, respectively). There was no correlation between BMD or SOS and FT(4), TT(3) 
      or duration of hyperthyroidism. BSAP and DPD positively correlated with FT(4) and 
      TT(3) (P<0.05). CONCLUSIONS: This study suggests that hyperthyroidism affects 
      bone mineralization especially during the early postmenopausal period, and the 
      effect is mainly at the cortical bone.
FAU - Ben-Shlomo, A
AU  - Ben-Shlomo A
AD  - Endocrine Institute, Assaf Harofeh Medical Center, Zerifin 70300, Israel.
FAU - Hagag, P
AU  - Hagag P
FAU - Evans, S
AU  - Evans S
FAU - Weiss, M
AU  - Weiss M
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Maturitas
JT  - Maturitas
JID - 7807333
RN  - 0 (Amino Acids)
RN  - 9002-71-5 (Thyrotropin)
RN  - 90032-33-0 (deoxypyridinoline)
RN  - EC 3.1.3.1 (Alkaline Phosphatase)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Absorptiometry, Photon
MH  - Adult
MH  - Aged
MH  - Alkaline Phosphatase/blood
MH  - Amino Acids/urine
MH  - Bone Density
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Hyperthyroidism/blood/complications/*physiopathology
MH  - Middle Aged
MH  - Osteoporosis, Postmenopausal/blood/complications/*physiopathology
MH  - Thyrotropin/blood
MH  - Thyroxine/blood
EDAT- 2001/07/14 10:00
MHDA- 2001/08/24 10:01
CRDT- 2001/07/14 10:00
PHST- 2001/07/14 10:00 [pubmed]
PHST- 2001/08/24 10:01 [medline]
PHST- 2001/07/14 10:00 [entrez]
AID - S0378-5122(00)00179-1 [pii]
AID - 10.1016/s0378-5122(00)00179-1 [doi]
PST - ppublish
SO  - Maturitas. 2001 Jul 25;39(1):19-27. doi: 10.1016/s0378-5122(00)00179-1.