PMID- 11453240
OWN - NLM
STAT- MEDLINE
DCOM- 20010927
LR  - 20221207
IS  - 0022-3492 (Print)
IS  - 0022-3492 (Linking)
VI  - 72
IP  - 6
DP  - 2001 Jun
TI  - The effect of antimicrobial periodontal treatment on circulating tumor necrosis 
      factor-alpha and glycated hemoglobin level in patients with type 2 diabetes.
PG  - 774-8
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) may play an important role in 
      insulin resistance. In this study, we hypothesized that TNF-alpha produced due to 
      periodontal inflammation synergistically affects insulin resistance as well as 
      TNF-alpha produced from adipose tissues in insulin-resistant type 2 diabetes 
      patients. Therefore, to understand the effects of antimicrobial periodontal 
      therapy on serum TNF-alpha concentration and subsequent metabolic control of 
      diabetes, we examined the periodontal and diabetic status on 13 type-2 diabetes 
      patients. METHODS: These patients were treated with local minocycline 
      administration in every periodontal pocket around all existing teeth once a week 
      for a month. Before and after treatment, the number of total bacteria in the 
      periodontal pockets and circulating TNF-alpha concentration were measured and the 
      HbA1c value was assessed. RESULTS: Antimicrobial therapy significantly reduced 
      the number of microorganisms in periodontal pockets (P <0.01). After treatment, 
      the circulating TNF-alpha level was significantly reduced (P <0.015). The HbA1c 
      value was also reduced significantly (P <0.007). In addition, the 6 patients who 
      were not receiving insulin therapy demonstrated decreased fasting insulin levels 
      (P <0.03), and HOMA-R (P <0.03) indices. The average reductions in circulating 
      TNF-alpha concentration and HbA1c value were 0.49 pg/ml and 0.8%, respectively. 
      CONCLUSION: The results indicate that anti-infectious treatment is effective in 
      improving metabolic control in diabetics, possibly through reduced serum 
      TNF-alpha and improved insulin resistance.
FAU - Iwamoto, Y
AU  - Iwamoto Y
AD  - Department of Periodontology and Endodontology, Okayama University Dental School, 
      Japan.
FAU - Nishimura, F
AU  - Nishimura F
FAU - Nakagawa, M
AU  - Nakagawa M
FAU - Sugimoto, H
AU  - Sugimoto H
FAU - Shikata, K
AU  - Shikata K
FAU - Makino, H
AU  - Makino H
FAU - Fukuda, T
AU  - Fukuda T
FAU - Tsuji, T
AU  - Tsuji T
FAU - Iwamoto, M
AU  - Iwamoto M
FAU - Murayama, Y
AU  - Murayama Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Periodontol
JT  - Journal of periodontology
JID - 8000345
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - FYY3R43WGO (Minocycline)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anti-Bacterial Agents/administration & dosage/*therapeutic use
MH  - Blood Glucose/analysis
MH  - Body Mass Index
MH  - Dental Plaque/therapy
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Fasting
MH  - Female
MH  - Follow-Up Studies
MH  - Glycated Hemoglobin/*analysis
MH  - Humans
MH  - Insulin/blood
MH  - Insulin Resistance
MH  - Male
MH  - Middle Aged
MH  - Minocycline/administration & dosage/*therapeutic use
MH  - Periodontal Diseases/blood/complications/*drug therapy
MH  - Periodontal Index
MH  - Periodontal Pocket/drug therapy
MH  - Periodontitis/drug therapy
MH  - Statistics as Topic
MH  - Statistics, Nonparametric
MH  - Tumor Necrosis Factor-alpha/*analysis
EDAT- 2001/07/17 10:00
MHDA- 2001/09/28 10:01
CRDT- 2001/07/17 10:00
PHST- 2001/07/17 10:00 [pubmed]
PHST- 2001/09/28 10:01 [medline]
PHST- 2001/07/17 10:00 [entrez]
AID - 10.1902/jop.2001.72.6.774 [doi]
PST - ppublish
SO  - J Periodontol. 2001 Jun;72(6):774-8. doi: 10.1902/jop.2001.72.6.774.