PMID- 11454071
OWN - NLM
STAT- MEDLINE
DCOM- 20011101
LR  - 20190921
IS  - 0105-6263 (Print)
IS  - 0105-6263 (Linking)
VI  - 24
IP  - 4
DP  - 2001 Aug
TI  - Aneuploidy in spermatozoa of infertile men with teratozoospermia.
PG  - 197-205
AB  - Recent studies have shown that aneuploidy in spermatozoa of infertile men with 
      poor semen quality is increased. The purpose of this study was to determine 
      whether poor sperm morphology is associated with the incidence of spermatozoa 
      with numerical chromosome abnormalities. Semen samples from 20 infertile 
      teratozoospermic men were studied using multicolour fluorescence in situ 
      hybridization (FISH). Men were divided into four groups according to the 
      proportion of normal sperm morphology: infertile men with <10% (group A, n=7), 
      10-19% (group B, n=6), and 20-29% (group C, n=7) of morphologically normal 
      spermatozoa, and controls (group D, n=5) with > or =30% normal forms. Two 
      hybridizations were performed. All the samples were analysed using probes for 
      chromosomes 1 and 7 and, in addition, in group A and in controls with normal 
      semen parameters probes for chromosomes X, Y and 18 were also used. Ten thousand 
      spermatozoa were scored per hybridization. Severely teratozoospermic men (<10% 
      normal forms) had significantly higher frequency of disomy 7, 18, YY, XY and 
      diploidy in their spermatozoa when compared with controls. The results suggest 
      that poor sperm morphology is associated with numerical chromosome abnormalities 
      of spermatozoa. Severely teratozoospermic men may be at an increased risk of 
      producing aneuploid offspring.
FAU - Harkonen, K
AU  - Harkonen K
AD  - Department of Medical Genetics, University of Turku, Kiinamyllynkatu 20, 20520 
      Turku, Finland.
FAU - Suominen, J
AU  - Suominen J
FAU - Lahdetie, J
AU  - Lahdetie J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Androl
JT  - International journal of andrology
JID - 8000141
SB  - IM
MH  - Adult
MH  - *Aneuploidy
MH  - *Chromosomes, Human, Pair 1
MH  - *Chromosomes, Human, Pair 18
MH  - *Chromosomes, Human, Pair 7
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Infertility, Male/*genetics
MH  - Male
MH  - Spermatozoa
MH  - *X Chromosome
MH  - *Y Chromosome
EDAT- 2001/07/17 10:00
MHDA- 2001/11/03 10:01
CRDT- 2001/07/17 10:00
PHST- 2001/07/17 10:00 [pubmed]
PHST- 2001/11/03 10:01 [medline]
PHST- 2001/07/17 10:00 [entrez]
AID - ija280 [pii]
AID - 10.1046/j.1365-2605.2001.00280.x [doi]
PST - ppublish
SO  - Int J Androl. 2001 Aug;24(4):197-205. doi: 10.1046/j.1365-2605.2001.00280.x.