PMID- 11454089
OWN - NLM
STAT- MEDLINE
DCOM- 20010809
LR  - 20190722
IS  - 0011-9059 (Print)
IS  - 0011-9059 (Linking)
VI  - 40
IP  - 4
DP  - 2001 Apr
TI  - Psoriasis vulgaris and acute guttate psoriasis in a family.
PG  - 285-7
AB  - A 33-year-old man (Case 1) developed scaling and erythema on the extensor side of 
      his extremities, head, and back, 3 years before his first visit to our hospital. 
      The lesions spread out to form several plaques and became persistent (Fig. 1a). 
      Serum antistreptolysin O (ASO) was within the normal range and a pharyngeal 
      culture showed normal flora. Histologic findings were compatible with psoriasis 
      vulgaris (Fig. 1b). Topical steroid therapy was effective; however, scaling and 
      erythema persisted. The 8-year-old daughter (Case 2) of Case 1 had suffered 
      severe tonsillitis 2 months prior to the skin eruptions. Numerous rain drop-like 
      scaly papules appeared on her legs and generalized rapidly (Fig. 2a). Her tonsils 
      were swollen and reddish. Streptococcus pyogenes was detected by pharyngeal 
      smear. The ASO value was at a high level. Histologic examination showed slightly 
      elongated rete ridges, focal lack of the granular layer, parakeratosis, mild 
      spongiosis, and exostosis of neutrophils (Fig. 2b). She was diagnosed with acute 
      guttate psoriasis. Administration of oral antimicrobials reduced the ASO value 
      and led to remission of the disease. After 1 month of antimicrobial treatment, 
      the erythematous papules disappeared. The human leukocyte antigen (HLA) typing of 
      the father was HLA-A24, A31, B7, B39, and Cw7, and that of the daughter was 
      HLA-A24, A31, B39, and Cw7. Both possessed HLA-A24, B39, and Cw7. The HLA typing 
      of other family members was also studied. The mother had HLA-A11, A24, B39, B62, 
      Cw4, and Cw7, and her son had HLA-A11, A24, B7, B62, Cw4, and Cw7. The result of 
      HLA typing is shown in Table 1. Lymphocyte stimulating test was performed using 
      heat-killed S. pyogenes which were boiled at 70 degrees C for 10 min and 
      sonicated. The stimulation index was twofold higher in the daughter than in the 
      father (Fig. 3).
FAU - Banno, T
AU  - Banno T
AD  - Department of Dermatology, Institute of Clinical Medicine, University of Tsukuba, 
      1-1-1 Tennodai Tsukuba, Ibaraki 305-8575, Japan.
FAU - Fujisawa, H
AU  - Fujisawa H
FAU - Satomi, H
AU  - Satomi H
FAU - Imakado, S
AU  - Imakado S
FAU - Otsuka, F
AU  - Otsuka F
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Int J Dermatol
JT  - International journal of dermatology
JID - 0243704
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Child
MH  - Family Health
MH  - Female
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Psoriasis/genetics/*pathology
MH  - Skin/*pathology
EDAT- 2001/07/17 10:00
MHDA- 2001/08/10 10:01
CRDT- 2001/07/17 10:00
PHST- 2001/07/17 10:00 [pubmed]
PHST- 2001/08/10 10:01 [medline]
PHST- 2001/07/17 10:00 [entrez]
AID - ijd1212-3 [pii]
AID - 10.1046/j.1365-4362.2001.01212-3.x [doi]
PST - ppublish
SO  - Int J Dermatol. 2001 Apr;40(4):285-7. doi: 10.1046/j.1365-4362.2001.01212-3.x.