PMID- 11457573
OWN - NLM
STAT- MEDLINE
DCOM- 20010913
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 308
IP  - 2
DP  - 2001 Aug 3
TI  - Rapid induction of neurotrophin mRNAs in rat glial cell cultures by Semax, an 
      adrenocorticotropic hormone analog.
PG  - 115-8
AB  - The proliferation, differentiation and survival of neuronal and glial cells are 
      affected by a number of neurotrophic factors, such as nerve growth factor (NGF), 
      brain-derived neurotrophic factor (BDNF) and others. In a previous study, we 
      observed the effects of 'Semax' (Met-Glu-His-Phe-Pro-Gly-Pro), the 
      physiologically active analogue of adrenocorticotropic hormone(4--10), on 
      neuronal cell survival in vitro. We hypothesized that these effects may be 
      mediated by the regulation of expression of some neurotrophic factors. To test 
      this hypothesis we analyzed NGF and BDNF gene expression in glial cells obtained 
      from the basal forebrain of newborn rats, following in vitro treatment with 
      'Semax'. We observed changes in mRNA levels for both the NGF and BDNF genes. The 
      greatest increase in expression was found after 30 min of 'Semax' administration. 
      At this time, BDNF mRNA level was increased eight-fold in comparison with 
      control, and NGF mRNA level was increased five-fold.
FAU - Shadrina, M I
AU  - Shadrina MI
AD  - Institute of Molecular Genetics, Russian Academy of Sciences, Kurchatov square 2, 
      123182 Moscow, Russia.
FAU - Dolotov, O V
AU  - Dolotov OV
FAU - Grivennikov, I A
AU  - Grivennikov IA
FAU - Slominsky, P A
AU  - Slominsky PA
FAU - Andreeva, L A
AU  - Andreeva LA
FAU - Inozemtseva, L S
AU  - Inozemtseva LS
FAU - Limborska, S A
AU  - Limborska SA
FAU - Myasoedov, N F
AU  - Myasoedov NF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nootropic Agents)
RN  - 0 (Peptide Fragments)
RN  - 0 (RNA, Messenger)
RN  - 80714-61-0 (ACTH (4-7), Pro-Gly-Pro-)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Adrenocorticotropic Hormone/analogs & derivatives/*pharmacology
MH  - Animals
MH  - Animals, Newborn
MH  - Basal Nucleus of Meynert/drug effects/metabolism
MH  - Brain/*drug effects/growth & development/metabolism
MH  - Brain-Derived Neurotrophic Factor/biosynthesis/genetics
MH  - Cell Differentiation/drug effects/genetics
MH  - Cell Division/drug effects/genetics
MH  - Cell Survival/drug effects/physiology
MH  - Cells, Cultured/drug effects/metabolism
MH  - Gene Expression Regulation/*drug effects/physiology
MH  - Nerve Growth Factor/biosynthesis/genetics
MH  - Nerve Growth Factors/biosynthesis/*genetics
MH  - Neuroglia/cytology/*drug effects/metabolism
MH  - Nootropic Agents/*pharmacology
MH  - Peptide Fragments/*pharmacology
MH  - RNA, Messenger/*drug effects/metabolism
MH  - Rats
MH  - Signal Transduction/drug effects/genetics
EDAT- 2001/07/18 10:00
MHDA- 2001/09/14 10:01
CRDT- 2001/07/18 10:00
PHST- 2001/07/18 10:00 [pubmed]
PHST- 2001/09/14 10:01 [medline]
PHST- 2001/07/18 10:00 [entrez]
AID - S0304-3940(01)01994-2 [pii]
AID - 10.1016/s0304-3940(01)01994-2 [doi]
PST - ppublish
SO  - Neurosci Lett. 2001 Aug 3;308(2):115-8. doi: 10.1016/s0304-3940(01)01994-2.