PMID- 11458504
OWN - NLM
STAT- MEDLINE
DCOM- 20010809
LR  - 20190616
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 938
DP  - 2001 Jun
TI  - Dendritic cell development from common myeloid progenitors.
PG  - 167-73; discussion 173-4
AB  - Dendritic cells (DCs) are professional antigen-presenting cells which both 
      initiate adaptive immune responses and control tolerance to self-antigens. It has 
      been suggested that these different effects on responder cells depend on subsets 
      of DCs arising from either myeloid or lymphoid hematopoietic origins. In this 
      model, CD8 alpha+ Mac-1- DCs are supposed to be of lymphoid while CD8 alpha- 
      Mac-1+ DCs are supposed to be of myeloid origin. Here we summarize our findings 
      that both CD8 alpha+ and CD8 alpha- DCs can arise from clonogenic common myeloid 
      progenitors (CMPs) in both thymus and spleen. Therefore CD8 alpha expression DCs 
      does not indicate a lymphoid origin and differences among CD8 alpha+ and CD8 
      alpha- DCs might rather reflect maturation status than ontogeny. On the basis of 
      transplantation studies, it seems likely that most of the DCs in secondary 
      lymphoid organs and a substantial fraction of thymic DCs are myeloid-derived.
FAU - Manz, M G
AU  - Manz MG
AD  - Department of Pathology and Developmental Biology, B261 Beckman Center, Stanford 
      University School of Medicine, 279 Campus Drive, Stanford, California 94305-5428, 
      USA. manz@stanford.edu
FAU - Traver, D
AU  - Traver D
FAU - Akashi, K
AU  - Akashi K
FAU - Merad, M
AU  - Merad M
FAU - Miyamoto, T
AU  - Miyamoto T
FAU - Engleman, E G
AU  - Engleman EG
FAU - Weissman, I L
AU  - Weissman IL
LA  - eng
GR  - 5T32 AI-07290/AI/NIAID NIH HHS/United States
GR  - CA42551/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Antigens, Differentiation)
RN  - 0 (CD8 Antigens)
RN  - 0 (Macrophage-1 Antigen)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Antigens, Differentiation/analysis
MH  - Bone Marrow Cells/cytology
MH  - CD8 Antigens/analysis
MH  - Cell Differentiation
MH  - Cell Lineage
MH  - Clone Cells/cytology
MH  - Dendritic Cells/classification/*cytology
MH  - Hematopoietic Stem Cell Transplantation
MH  - Hematopoietic Stem Cells/*cytology
MH  - Macrophage-1 Antigen/analysis
MH  - Mice
MH  - Myeloid Cells/*cytology
MH  - Radiation Chimera
MH  - Thymus Gland/cytology
MH  - Transcription Factors/deficiency/genetics/physiology
EDAT- 2001/07/19 10:00
MHDA- 2001/08/10 10:01
CRDT- 2001/07/19 10:00
PHST- 2001/07/19 10:00 [pubmed]
PHST- 2001/08/10 10:01 [medline]
PHST- 2001/07/19 10:00 [entrez]
AID - 10.1111/j.1749-6632.2001.tb03586.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2001 Jun;938:167-73; discussion 173-4. doi: 
      10.1111/j.1749-6632.2001.tb03586.x.