PMID- 11460687
OWN - NLM
STAT- MEDLINE
DCOM- 20010830
LR  - 20191105
IS  - 0141-1136 (Print)
IS  - 0141-1136 (Linking)
VI  - 50
IP  - 1-5
DP  - 2000 Jul-Dec
TI  - Estrogenic and CYP1A response of mummichogs and sunshine bass to sewage effluent.
PG  - 175-9
AB  - Recent studies demonstrating feminization of effluent-exposed wild-caught male 
      fish in the UK have prompted much research regarding the estrogenic activity of 
      effluent from municipal sewage treatment plants (MSTPs). To investigate the 
      estrogenicity and cytochrome P450 1A (CYP1A) induction potency of MSTP effluent, 
      two species of fish, adult male mummichogs, Fundulus heteroclitus, and juvenile 
      sunshine bass, Morone saxatilis x Morone chrysops, were exposed to un-chlorinated 
      effluent (75% effluent, 25% seawater) from a large MSTP in Yonkers, NY, USA. 
      After a 21-day static-daily (75%) renewal exposure, significant elevations over 
      controls were observed in levels of vitellogenin (VtG) in plasma (1730%) and 
      liver (131%) in effluent-exposed sunshine bass. In contrast, hepatic VtG was not 
      elevated in mummichogs; plasma VtG was not measured in this species. Effluent 
      exposure elevated hepatic CYP1A protein (140-145%) and 
      ethoxyresorufin-O-deethylase (EROD) activity (408-598%) in both species. These 
      findings suggest ontogenetic and/or species differences in response to estrogenic 
      compounds in MSTP effluent. Furthermore, the elevation of CYP1A in response to 
      sewage effluent exposure indicates the presence of additional compounds that may 
      alter xenobiotic and/or steroid biotransformation in fish.
FAU - McArdle, M
AU  - McArdle M
AD  - Marine Sciences Research Center, State University of New York, Stony Brook, NY 
      11794, USA.
FAU - Elskus, A
AU  - Elskus A
FAU - McElroy, A
AU  - McElroy A
FAU - Larsen, B
AU  - Larsen B
FAU - Benson, W
AU  - Benson W
FAU - Schlenk, D
AU  - Schlenk D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Mar Environ Res
JT  - Marine environmental research
JID - 9882895
RN  - 0 (Estrogens)
RN  - 0 (Sewage)
RN  - 0 (Vitellogenins)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
SB  - IM
MH  - Animals
MH  - Bass/*metabolism
MH  - Cytochrome P-450 CYP1A1/*metabolism
MH  - Estrogens/*metabolism
MH  - Killifishes/*metabolism
MH  - Liver/drug effects/metabolism
MH  - Male
MH  - *Sewage
MH  - United Kingdom
MH  - Vitellogenins/metabolism
EDAT- 2001/07/20 10:00
MHDA- 2001/08/31 10:01
CRDT- 2001/07/20 10:00
PHST- 2001/07/20 10:00 [pubmed]
PHST- 2001/08/31 10:01 [medline]
PHST- 2001/07/20 10:00 [entrez]
AID - S0141-1136(00)00074-X [pii]
AID - 10.1016/s0141-1136(00)00074-x [doi]
PST - ppublish
SO  - Mar Environ Res. 2000 Jul-Dec;50(1-5):175-9. doi: 10.1016/s0141-1136(00)00074-x.