PMID- 11463447
OWN - NLM
STAT- MEDLINE
DCOM- 20010809
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 128
IP  - 2
DP  - 2001 Jul 15
TI  - Translocation (8;17;15;21)(q22;q23;q15;q22) in acute myeloid leukemia (M2). a 
      four-way variant of t(8;21).
PG  - 104-7
AB  - We report the results of cytogenetic, fluorescence in situ hybridization (FISH) 
      and molecular analyses in a 15-year-old boy diagnosed with acute myeloid leukemia 
      subtype M2 (AML-M2). Cytogenetic and FISH analyses, the latter with whole 
      chromosome painting probes, revealed a complex translocation involving four 
      chromosomes: t(8;17;15;21)(q22;q23;q15;q22). The observation of breakpoints at 
      8q22 and 21q22 suggested a rearrangement of the ETO and AML1 genes, respectively. 
      Using a dual-color FISH test with ETO and AML1 probes, we demonstrated an 
      AML1/ETO fusion signal on the derivative chromosome 8. Reverse 
      transcription-polymerase chain reaction (RT-PCR) analysis showed the presence of 
      AML1/ETO fusion transcripts identical to those found in classical t(8;21). The 
      present case highlights the relevant role of the rearranged chromosome 8, which 
      encodes the AML1/ETO fusion product in the pathogenesis of AML-M2.
FAU - Vieira, L
AU  - Vieira L
AD  - Centro de Genetica Humana, Instituto Nacional de Saude Dr. Ricardo Jorge, Av. 
      Padre Cruz, 1649-016, Lisboa, Portugal. luis.vieira@insa.min-saude.pt
FAU - Oliveira, V
AU  - Oliveira V
FAU - Ambrosio, A P
AU  - Ambrosio AP
FAU - Marques, B
AU  - Marques B
FAU - Pereira, A M
AU  - Pereira AM
FAU - Hagemeijer, A
AU  - Hagemeijer A
FAU - Boavida, M G
AU  - Boavida MG
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (AML1-ETO fusion protein, human)
RN  - 0 (Core Binding Factor Alpha 2 Subunit)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (RUNX1 Translocation Partner 1 Protein)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adolescent
MH  - Chromosomes, Human, Pair 15/genetics
MH  - Chromosomes, Human, Pair 21/*genetics
MH  - Chromosomes, Human, Pair 7/genetics
MH  - Chromosomes, Human, Pair 8/*genetics
MH  - Core Binding Factor Alpha 2 Subunit
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - Male
MH  - Oncogene Proteins, Fusion/genetics
MH  - RUNX1 Translocation Partner 1 Protein
MH  - Transcription Factors/genetics
MH  - Translocation, Genetic/*genetics
EDAT- 2001/07/21 10:00
MHDA- 2001/08/10 10:01
CRDT- 2001/07/21 10:00
PHST- 2001/07/21 10:00 [pubmed]
PHST- 2001/08/10 10:01 [medline]
PHST- 2001/07/21 10:00 [entrez]
AID - S0165460801004046 [pii]
AID - 10.1016/s0165-4608(01)00404-6 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2001 Jul 15;128(2):104-7. doi: 
      10.1016/s0165-4608(01)00404-6.