PMID- 11463557
OWN - NLM
STAT- MEDLINE
DCOM- 20011004
LR  - 20190513
IS  - 1010-7940 (Print)
IS  - 1010-7940 (Linking)
VI  - 20
IP  - 2
DP  - 2001 Aug
TI  - Surgical treatment of lung cancer invading chest wall: a retrospective analysis 
      of 110 patients.
PG  - 356-60
AB  - OBJECTIVE: To retrospectively assess the results of surgical treatment in a 
      consecutive series of 110 patients with Stage IIb and IIIa non small cell lung 
      cancer (NSCLC) invading chest wall. METHODS: A series of 110 patients underwent 
      surgery for Stage IIb and IIIa NSCLC with involvement of chest wall. There were 
      101 male and 9 female patients, mean age was 61.4 (range 32--74), 52 (47.3%) of 
      them complaining for chest pain. Surgical procedures were pneumonectomy in seven 
      patients (6.4%), lobectomy in 73 (66.4%), bi-lobectomy in six (5.4%) and wedge 
      resection in 24 (21.8%). In 63 patients (57.3%) an extrapleural resection was 
      performed while in the other 47 (42.7%) an 'en bloc' resection of tumor with 
      chest wall was required. In 22 patients (76.3%) repair was achieved by muscle 
      flap while in 8 (26.7%) a prosthesis was required. Five-year survival was 
      computed using the Kaplan--Meier method; P values correspond to the log-rank 
      test. RESULTS: There were neither intraoperative nor postoperative deaths. 
      Postoperative staging revealed 83 T3N0M0, 17 T3N1M0 and 10 T3N2M0. Mean 
      postoperative hospital stay was 17.7 days (range 5--40). For N0 patients 5 year 
      survival was 47% (39/83) and no significant difference was noted when 
      extrapleural and 'en bloc' resection groups were compared (P = 0.08). In N1/N2 
      patients no survival was observed (0/27) and comparison between surgical 
      procedures was not statistically significant (P = 0.41). Moreover when N0 
      patients were compared with N1 patients the difference in survival was 
      significant for both extrapleural (P = 0.02) and 'en bloc' (P = 0.04) groups. No 
      difference was noted when the two surgical procedures were compared independently 
      form N status (P = 0.94). Within the group of patients undergone 'en bloc' 
      resection survival was significantly better for N0 patients as in the group of 
      extrapleural resection. CONCLUSION: Surgical treatment of Stage IIb and IIIa 
      NSCLC invading chest wall by extrapleural or 'en bloc' resection is widely 
      adopted and justified by the good results in terms of morbidity and relief of 
      pain. Survival is always depending on the N status.
FAU - Elia, S
AU  - Elia S
AD  - Department of Thoracic Surgery, Medical Faculty, University Federico II, Naples, 
      Italy. elia@unina.it
FAU - Griffo, S
AU  - Griffo S
FAU - Gentile, M
AU  - Gentile M
FAU - Costabile, R
AU  - Costabile R
FAU - Ferrante, G
AU  - Ferrante G
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Eur J Cardiothorac Surg
JT  - European journal of cardio-thoracic surgery : official journal of the European 
      Association for Cardio-thoracic Surgery
JID - 8804069
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Non-Small-Cell Lung/mortality/*pathology/*surgery
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/mortality/*pathology/*surgery
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Retrospective Studies
EDAT- 2001/07/21 10:00
MHDA- 2001/10/05 10:01
CRDT- 2001/07/21 10:00
PHST- 2001/07/21 10:00 [pubmed]
PHST- 2001/10/05 10:01 [medline]
PHST- 2001/07/21 10:00 [entrez]
AID - S1010-7940(01)00735-7 [pii]
AID - 10.1016/s1010-7940(01)00735-7 [doi]
PST - ppublish
SO  - Eur J Cardiothorac Surg. 2001 Aug;20(2):356-60. doi: 
      10.1016/s1010-7940(01)00735-7.