PMID- 11463992 OWN - NLM STAT- MEDLINE DCOM- 20010906 LR - 20171101 IS - 0001-5792 (Print) IS - 0001-5792 (Linking) VI - 105 IP - 3 DP - 2001 TI - Successful allogeneic bone marrow transplantation. Crucial roles of stromal cells in prevention of graft rejection. PG - 172-8 AB - We have previously found that a major histocompatibility complex (MHC) restriction exists between pluripotent hemopoietic stem cells (P-HSCs) and stromal cells. Based on this finding, we have recently found using chimerism-resistant mouse combinations that successful allogeneic (allo) BMT can be executed by recruiting donor bone marrow stromal cells. The strategies include donor bone grafts under the skin, injection of whole bone marrow cells (BMCs) including stromal cells via the portal vein (PV), and injection of whole BMCs directly into the bone marrow cavity (intra-bone marrow [IBM] injection). In this paper, we show how stromal cells play crucial roles in overcoming chimerism-resistant allo BMT. CI - Copyright 2001 S. Karger AG, Basel FAU - Ikehara, S AU - Ikehara S AD - First Department of Pathology, Transplantation Center, Kansai Medical University, Moriguchi City, Japan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - Switzerland TA - Acta Haematol JT - Acta haematologica JID - 0141053 SB - IM MH - Animals MH - Autoimmune Diseases/therapy MH - *Bone Marrow Transplantation/immunology/standards MH - Graft Rejection/immunology/prevention & control MH - Histocompatibility MH - Humans MH - Stromal Cells/immunology MH - Transplantation, Homologous RF - 23 EDAT- 2001/07/21 10:00 MHDA- 2001/09/08 10:01 CRDT- 2001/07/21 10:00 PHST- 2001/07/21 10:00 [pubmed] PHST- 2001/09/08 10:01 [medline] PHST- 2001/07/21 10:00 [entrez] AID - 46561 [pii] AID - 10.1159/000046561 [doi] PST - ppublish SO - Acta Haematol. 2001;105(3):172-8. doi: 10.1159/000046561.