PMID- 11464148
OWN - NLM
STAT- MEDLINE
DCOM- 20010809
LR  - 20200930
IS  - 1525-4135 (Print)
IS  - 1525-4135 (Linking)
VI  - 27
IP  - 3
DP  - 2001 Jul 1
TI  - Mismatched human leukocyte antigen alleles protect against heterosexual HIV 
      transmission.
PG  - 277-80
AB  - Genetic variation at the human leukocyte antigen (HLA) loci has been shown to be 
      an important risk factor for progression to HIV disease, but its significance in 
      infection is less well understood. We have investigated its role in HIV 
      transmission in a cohort of individuals at risk for heterosexual infection. 
      Analysis of over 80 individuals revealed that that the degree of concordance at 
      HLA A, B, and DR loci differs significantly between transmitting and 
      nontransmitting couples at risk for heterosexual HIV transmission (p <.02), 
      suggesting that allogeneic immune responses may confer a degree of protection 
      against HIV infection. Analysis of the frequencies of specific alleles at the A, 
      B, and DR loci revealed a significantly higher frequency of HLA DR5 among exposed 
      uninfected individuals, relative to population controls.
FAU - Lockett, S F
AU  - Lockett SF
AD  - Centre for HIV Research, Institute of Cell, Animal and Population Biology, 
      University of Edinburgh, Edinburgh, Scotland.
FAU - Robertson, J R
AU  - Robertson JR
FAU - Brettle, R P
AU  - Brettle RP
FAU - Yap, P L
AU  - Yap PL
FAU - Middleton, D
AU  - Middleton D
FAU - Leigh Brown, A J
AU  - Leigh Brown AJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Alleles
MH  - Cohort Studies
MH  - Disease Progression
MH  - Disease Susceptibility
MH  - Female
MH  - Gene Frequency
MH  - Genes, Recessive
MH  - Genetic Predisposition to Disease
MH  - Genetic Variation
MH  - HIV Infections/genetics/prevention & control/*transmission
MH  - HLA Antigens/*genetics/immunology
MH  - HLA-A Antigens/genetics/immunology
MH  - HLA-B Antigens/genetics/immunology
MH  - HLA-DR Antigens/genetics/immunology
MH  - Heterosexuality
MH  - Heterozygote
MH  - Humans
MH  - Male
MH  - Risk Factors
EDAT- 2001/07/21 10:00
MHDA- 2001/08/10 10:01
CRDT- 2001/07/21 10:00
PHST- 2001/07/21 10:00 [pubmed]
PHST- 2001/08/10 10:01 [medline]
PHST- 2001/07/21 10:00 [entrez]
AID - 10.1097/00126334-200107010-00010 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2001 Jul 1;27(3):277-80. doi: 
      10.1097/00126334-200107010-00010.