PMID- 11465029
OWN - NLM
STAT- MEDLINE
DCOM- 20010816
LR  - 20190513
IS  - 1467-5463 (Print)
IS  - 1467-5463 (Linking)
VI  - 1
IP  - 2
DP  - 2000 May
TI  - Epitope scanning using virtual matrix-based algorithms.
PG  - 179-89
AB  - Protein sequence and expression databases (transcriptomes) contain the 
      information required to identify epitopes capable of generating protective immune 
      responses in humans. A key event in the initiation of an immune response against 
      disease is the presentation of antigenic peptide epitopes to T cells by human 
      leukocyte antigen (HLA) molecules. Computational filtering tools that allow the 
      prediction of HLA/epitope interaction can be applied to sequence databases to 
      select for candidate epitopes, thus minimising the subsequent amount of 
      laboratory work. Here, the basic principles of epitope prediction and a summary 
      of the available prediction approaches are presented, with a particular emphasis 
      on the use of algorithms based on virtual HLA-II quantitative matrices, capable 
      of predicting promiscuous HLA-II ligands.
FAU - Raddrizzani, L
AU  - Raddrizzani L
AD  - Department of Genomics and Information Sciences, Hoffmann-La Roche, Nutley, NJ 
      07110, USA. laura.raddrizzani@roche.com
FAU - Hammer, J
AU  - Hammer J
LA  - eng
PT  - Journal Article
PL  - England
TA  - Brief Bioinform
JT  - Briefings in bioinformatics
JID - 100912837
RN  - 0 (Epitopes)
RN  - 0 (HLA Antigens)
RN  - 0 (Proteins)
SB  - IM
MH  - *Algorithms
MH  - Amino Acid Sequence
MH  - Antigen Presentation
MH  - Computational Biology
MH  - Databases, Factual
MH  - Epitopes/*genetics/metabolism
MH  - HLA Antigens/metabolism
MH  - Humans
MH  - Internet
MH  - Molecular Sequence Data
MH  - Proteins/genetics/immunology
MH  - Sequence Alignment/statistics & numerical data
MH  - Software
MH  - T-Lymphocytes/immunology
MH  - User-Computer Interface
EDAT- 2001/07/24 10:00
MHDA- 2001/08/17 10:01
CRDT- 2001/07/24 10:00
PHST- 2001/07/24 10:00 [pubmed]
PHST- 2001/08/17 10:01 [medline]
PHST- 2001/07/24 10:00 [entrez]
AID - 10.1093/bib/1.2.179 [doi]
PST - ppublish
SO  - Brief Bioinform. 2000 May;1(2):179-89. doi: 10.1093/bib/1.2.179.