PMID- 11466580
OWN - NLM
STAT- MEDLINE
DCOM- 20011228
LR  - 20161124
VI  - 25 Suppl 1
DP  - 2001 May
TI  - Association between polymorphisms in candidate genes and morbid obesity.
PG  - S19-21
AB  - Polymorphisms in a number of candidate genes have been reported to be associated 
      with obesity. We have determined the incidence of the following polymorphisms in 
      the following candidate genes in a group of 388 morbid obese patients (mean body 
      mass index (BMI) 52+/-8.01) who underwent gastric banding surgery: lipoprotein 
      lipase (LpL) t-93 g and N291S; peroxisome proliferator receptor gamma 
      (PPARgamma), P12A, P115Q and c1431t; peroxisome proliferator receptor alpha 
      (PPARalpha) L162V; beta-adrenergic receptor 2 (beta-AR 2), Q27E; beta-adrenergic 
      receptor 3 (beta-AR 3) W64R; uncoupling protein 1 (ucp-1), a-3826g, ucp-2, 45 bp 
      insertion. Only for the ucp2 polymorphism did we find a statistically significant 
      association with obesity. The beta-AR 3 W64R and ucp-1 a-3826g polymorphisms 
      influenced the rate of the development of obesity and may act synergistically.
FAU - Evans, D
AU  - Evans D
AD  - Medizinische Klinik, Universitatskrankenhaus Eppendorf, Martinistrasse 52, 20251 
      Hamburg, Germany. evans@uke.uni-hamburg.de
FAU - Wolf, A M
AU  - Wolf AM
FAU - Nellessen, U
AU  - Nellessen U
FAU - Ahle, S
AU  - Ahle S
FAU - Kortner, B
AU  - Kortner B
FAU - Kuhlmann, H W
AU  - Kuhlmann HW
FAU - Beisiegel, U
AU  - Beisiegel U
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Obes Relat Metab Disord
JT  - International journal of obesity and related metabolic disorders : journal of the 
      International Association for the Study of Obesity
JID - 9313169
RN  - 0 (Carrier Proteins)
RN  - 0 (Ion Channels)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (Mitochondrial Proteins)
RN  - 0 (Proteins)
RN  - 0 (UCP2 protein, human)
RN  - 0 (Uncoupling Protein 2)
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - Body Weight/*genetics
MH  - Carrier Proteins/*genetics
MH  - Female
MH  - Humans
MH  - Ion Channels
MH  - Male
MH  - *Membrane Transport Proteins
MH  - *Mitochondrial Proteins
MH  - Obesity, Morbid/*genetics
MH  - *Polymorphism, Genetic
MH  - Proteins
MH  - Uncoupling Protein 2
EDAT- 2001/07/24 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/07/24 10:00
PHST- 2001/07/24 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/07/24 10:00 [entrez]
AID - 10.1038/sj.ijo.0801690 [doi]
PST - ppublish
SO  - Int J Obes Relat Metab Disord. 2001 May;25 Suppl 1:S19-21. doi: 
      10.1038/sj.ijo.0801690.