PMID- 11468205
OWN - NLM
STAT- MEDLINE
DCOM- 20010906
LR  - 20220310
IS  - 1524-4539 (Electronic)
IS  - 0009-7322 (Linking)
VI  - 104
IP  - 4
DP  - 2001 Jul 24
TI  - Exercise pathophysiology in patients with primary pulmonary hypertension.
PG  - 429-35
AB  - BACKGROUND: Patients with primary pulmonary hypertension (PPH) have a pulmonary 
      vasculopathy that leads to exercise intolerance due to dyspnea and fatigue. To 
      better understand the basis of the exercise limitation in patients with PPH, 
      cardiopulmonary exercise testing (CPET) with gas exchange measurements, New York 
      Heart Association (NYHA) symptom class, and resting pulmonary hemodynamics were 
      studied. METHODS AND RESULTS: We retrospectively evaluated 53 PPH patients who 
      had right heart catheterization and cycle ergometer CPET studies to maximum 
      tolerance as part of their clinical workups. No adverse events occurred during 
      CPET. Reductions in peak O(2) uptake (VO(2)), anaerobic threshold, peak O(2) 
      pulse, rate of increase in VO(2), and ventilatory efficiency were consistently 
      found. NYHA class correlated well with the above parameters of aerobic function 
      and ventilatory efficiency but less well with resting pulmonary hemodynamics. 
      CONCLUSIONS: Patients with PPH can safely undergo noninvasive cycle ergometer 
      CPET to their maximal tolerance. The CPET abnormalities were consistent and 
      characteristic and correlated well with NYHA class.
FAU - Sun, X G
AU  - Sun XG
AD  - Department of Medicine, Harbor-UCLA Medical Center, Torrance, California, USA.
FAU - Hansen, J E
AU  - Hansen JE
FAU - Oudiz, R J
AU  - Oudiz RJ
FAU - Wasserman, K
AU  - Wasserman K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
SB  - IM
MH  - Adult
MH  - Blood Pressure/physiology
MH  - Exercise Test/methods
MH  - Exercise Tolerance/*physiology
MH  - Female
MH  - Heart Rate/physiology
MH  - Humans
MH  - Hypertension, Pulmonary/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Gas Exchange/physiology
MH  - Respiratory Function Tests
EDAT- 2001/07/27 10:00
MHDA- 2001/09/08 10:01
CRDT- 2001/07/27 10:00
PHST- 2001/07/27 10:00 [pubmed]
PHST- 2001/09/08 10:01 [medline]
PHST- 2001/07/27 10:00 [entrez]
AID - 10.1161/hc2901.093198 [doi]
PST - ppublish
SO  - Circulation. 2001 Jul 24;104(4):429-35. doi: 10.1161/hc2901.093198.