PMID- 11471110
OWN - NLM
STAT- MEDLINE
DCOM- 20010920
LR  - 20131121
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 184
IP  - 4
DP  - 2001 Aug 15
TI  - Susceptibility of human T cell leukemia virus type 1 to reverse-transcriptase 
      inhibitors: evidence for resistance to lamivudine.
PG  - 507-10
AB  - Nucleoside reverse-transcriptase (RT) inhibitors (NRTIs), including lamivudine 
      (3TC) and zidovudine (Zdv), are being evaluated for the treatment of human T cell 
      lymphotropic virus type 1 (HTLV-1)-associated disease. However, information on 
      the susceptibility of HTLV-1 to these drugs is limited. The activity of 5 NRTIs 
      on HTLV-1 RT was evaluated. IC(50) values for Zdv, zalcitabine (ddC), didanosine 
      (ddI), 3TC, and stavudine (d4T) were determined, using an enzymatic assay, for 5 
      HTLV-1 isolates and for reference wild-type and NRTI-resistant human 
      immunodeficiency virus type 1 (HIV-1). Both HTLV-1 and wild-type HIV-1 were 
      equally susceptible to Zdv, ddC, ddI, and d4T. In contrast, high-level resistance 
      to 3TC was found in all HTLV-1 isolates. The findings support the clinical use of 
      Zdv, ddC, ddI, and d4T but not of 3TC for the antiretroviral treatment of 
      HTLV-1-associated disease.
FAU - Garcia-Lerma, J G
AU  - Garcia-Lerma JG
AD  - HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, 
      National Center for Infectious Diseases, Centers for Disease Control and 
      Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA. jng5@cdc.gov
FAU - Nidtha, S
AU  - Nidtha S
FAU - Heneine, W
AU  - Heneine W
LA  - eng
PT  - Journal Article
DEP - 20010725
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Reverse Transcriptase Inhibitors)
RN  - 2T8Q726O95 (Lamivudine)
RN  - EC 2.7.7.49 (HIV Reverse Transcriptase)
RN  - EC 2.7.7.49 (RNA-Directed DNA Polymerase)
SB  - IM
MH  - Amino Acid Sequence
MH  - Deltaretrovirus Infections/virology
MH  - Drug Resistance, Microbial
MH  - HIV Infections/virology
MH  - HIV Reverse Transcriptase/drug effects/genetics
MH  - HIV-1/drug effects/enzymology
MH  - Human T-lymphotropic virus 1/*drug effects/enzymology
MH  - Humans
MH  - Lamivudine/*pharmacology
MH  - Microbial Sensitivity Tests/methods
MH  - Molecular Sequence Data
MH  - RNA-Directed DNA Polymerase/chemistry/genetics/*metabolism
MH  - Reverse Transcriptase Inhibitors/*pharmacology
EDAT- 2001/07/27 10:00
MHDA- 2001/09/21 10:01
CRDT- 2001/07/27 10:00
PHST- 2001/03/23 00:00 [received]
PHST- 2001/05/08 00:00 [revised]
PHST- 2001/07/27 10:00 [pubmed]
PHST- 2001/09/21 10:01 [medline]
PHST- 2001/07/27 10:00 [entrez]
AID - JID010340 [pii]
AID - 10.1086/322785 [doi]
PST - ppublish
SO  - J Infect Dis. 2001 Aug 15;184(4):507-10. doi: 10.1086/322785. Epub 2001 Jul 25.