PMID- 11471895
OWN - NLM
STAT- MEDLINE
DCOM- 20011207
LR  - 20221007
IS  - 0393-6155 (Print)
IS  - 0393-6155 (Linking)
VI  - 16
IP  - 2
DP  - 2001 Apr-Jun
TI  - Serum levels of interleukin-18 and sICAM-1 in patients affected by breast cancer: 
      preliminary considerations.
PG  - 126-9
AB  - Interleukin-18 (IL-18), a cytokine that plays an important role in the 
      T-cell-helper type 1 response, acts as an angiogenesis and tumor suppressor. 
      Intercellular adhesion molecule-1 (ICAM-1) has a potential role in 
      immunoregulation by mediating immune cell infiltration into the tissue. The aim 
      of this study was to evaluate IL-18 and soluble (s) ICAM-1 serum levels in breast 
      cancer (BCa) patients with liver (BCaM1 h) or bone (BCaM1 b) metastases compared 
      to BCa patients without metastases (BCaM0) and healthy donors (HDs). Furthermore, 
      since IL-18 enhances ICAM-1 expression, we investigated whether there was a 
      direct correlation between sICAM-1 and IL-18 serum levels. Serum IL-18 and 
      sICAM-1 levels were assayed by immunoenzymatic methods. The serum sICAM-1 levels 
      in the three groups of cancer patients were significantly higher (p<0.05) than 
      those of HDs. Serum IL-18 levels were significantly higher (p<0.05) in BCaM1h and 
      BCaM1b patients compared to BCaM0 patients and HDs. sICAM-1 proved to be closely 
      correlated with serum IL-18 levels in HDs, whereas a weaker correlation was found 
      in BCaM1h, BCaM1b and BCaM0 patients. The defective correlation between sICAM-1 
      and IL-18 found in cancer patients may contribute to our understanding of the 
      immunity upset occurring in cancer. Our data suggest that IL-18, irrespective of 
      its biological activity, could represent a marker for metastatic breast cancer.
FAU - Merendino, R A
AU  - Merendino RA
AD  - University of Messina Medical School, University Hospital G. Martino, Messina, 
      Italy.
FAU - Gangemi, S
AU  - Gangemi S
FAU - Ruello, A
AU  - Ruello A
FAU - Bene, A
AU  - Bene A
FAU - Losi, E
AU  - Losi E
FAU - Lonbardo, G
AU  - Lonbardo G
FAU - Purello-Dambrosio, F
AU  - Purello-Dambrosio F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Biol Markers
JT  - The International journal of biological markers
JID - 8712411
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Interleukin-18)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*blood
MH  - Bone Neoplasms/blood/secondary
MH  - Breast Neoplasms/*blood/pathology
MH  - Female
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/*blood
MH  - Interleukin-18/*blood
MH  - Liver Neoplasms/blood/secondary
MH  - Middle Aged
MH  - Neoplasm Staging
EDAT- 2001/07/27 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/07/27 10:00
PHST- 2001/07/27 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/07/27 10:00 [entrez]
AID - 10.1177/172460080101600207 [doi]
PST - ppublish
SO  - Int J Biol Markers. 2001 Apr-Jun;16(2):126-9. doi: 10.1177/172460080101600207.