PMID- 11472035
OWN - NLM
STAT- MEDLINE
DCOM- 20010913
LR  - 20061030
IS  - 1521-690X (Print)
IS  - 1521-690X (Linking)
VI  - 15
IP  - 2
DP  - 2001 Jun
TI  - Early surgical intervention and strategy in patients with multiple endocrine 
      neoplasia type 1.
PG  - 213-23
AB  - Patients with multiple endocrine neoplasia type 1 (MEN-1) are an unusual 
      challenge to the endocrine surgeon. Pituitary disease is often treated without 
      surgery, but nearly all patients will require parathyroidectomy for parathyroid 
      hyperplasia. Subtotal parathyroidectomy can be accomplished with a very low rate 
      of permanent hypoparathyroidism and an acceptable rate of recurrent 
      hyperparathyroidism. The treatment of pancreaticoduodenal disease is quite 
      controversial. Even when associated with the Zollinger-Ellison syndrome, early 
      and aggressive surgical treatment should be considered to influence the hormonal 
      syndrome as well as to address the malignant potential of both pancreatic and 
      duodenal tumours. This includes distal pancreatectomy, enucleation of pancreatic 
      head lesions, and duodenotomy with the resection of gastrinomas. Many patients 
      may be completely cured of the manifestations of their disease. As MEN-1 is an 
      uncommon entity, there are very few prospective, randomized data upon which to 
      base surgical judgements.
CI  - Copyright 2001 Harcourt Publishers Ltd.
FAU - Gauger, P G
AU  - Gauger PG
AD  - Department of Surgery, Division of Endocrine Surgery, University of Michigan 
      Hospital, Ann Arbor, Michigan, USA.
FAU - Thompson, N W
AU  - Thompson NW
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Best Pract Res Clin Endocrinol Metab
JT  - Best practice & research. Clinical endocrinology & metabolism
JID - 101120682
SB  - IM
MH  - Duodenum
MH  - Humans
MH  - Multiple Endocrine Neoplasia Type 1/*surgery
MH  - Pancreatectomy
MH  - Parathyroidectomy
RF  - 38
EDAT- 2001/07/27 10:00
MHDA- 2001/09/14 10:01
CRDT- 2001/07/27 10:00
PHST- 2001/07/27 10:00 [pubmed]
PHST- 2001/09/14 10:01 [medline]
PHST- 2001/07/27 10:00 [entrez]
AID - S1521690X01901368 [pii]
AID - 10.1053/beem.2001.0136 [doi]
PST - ppublish
SO  - Best Pract Res Clin Endocrinol Metab. 2001 Jun;15(2):213-23. doi: 
      10.1053/beem.2001.0136.