PMID- 11473798
OWN - NLM
STAT- MEDLINE
DCOM- 20010927
LR  - 20190901
IS  - 0379-0738 (Print)
IS  - 0379-0738 (Linking)
VI  - 120
IP  - 3
DP  - 2001 Sep 1
TI  - Application of solvent microextraction to the analysis of amphetamines and 
      phencyclidine in urine.
PG  - 165-71
AB  - A fast and simple method to detect some commonly abused illicit drugs, 
      amphetamine, methamphetamine, 3,4-methylendioxy-amphetamine (MDA), 
      3,4-methylendioxy-methamphetamine (MDMA), 3,4-methylendioxy-N-ethylamphetamine 
      (MDEA) and phencyclidine (PCP) in urine using solvent microextraction (SME) 
      combined with gas chromatography (GC) analysis has been developed. The extraction 
      is conducted by suspending a 2 microl drop of chloroform in a 2 ml urine sample. 
      Following 8 min of extraction, the organic solvent is withdrawn into the syringe 
      and injected into a GC with a pulsed discharge helium ionization detector 
      (PDHID). The effects of different extraction solvents and times, pH and sample 
      preparation were studied. The optimized method was capable of detecting drugs in 
      urine at concentrations below Substance Abuse and Mental Health Services 
      Administration (SAMHSA) established cut-off values for preliminary testing. Good 
      linearity and reproducibility of extraction were obtained. The limits of 
      detection were 0.5 microg/ml for amphetamine, 0.1 microg/ml for methamphetamine 
      and MDA, 0.05 microg/ml for MDMA, 0.025 microg/ml for MDEA and 0.015 microg/ml 
      for PCP. Relative standard deviation (R.S.D.) values ranged between 5 and 20% for 
      the studied drugs.
FAU - Casari, C
AU  - Casari C
AD  - Facolta di Farmacia, Universita del Piemonte Orientale, Viale Ferrucci 33, 
      I-28100, Novara, Italy.
FAU - Andrews, A R
AU  - Andrews AR
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Forensic Sci Int
JT  - Forensic science international
JID - 7902034
RN  - 0 (Amphetamines)
RN  - J1DOI7UV76 (Phencyclidine)
SB  - IM
MH  - Amphetamines/*urine
MH  - Chromatography, Gas/*methods
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Phencyclidine/*urine
MH  - Reproducibility of Results
EDAT- 2001/07/28 10:00
MHDA- 2001/09/28 10:01
CRDT- 2001/07/28 10:00
PHST- 2001/07/28 10:00 [pubmed]
PHST- 2001/09/28 10:01 [medline]
PHST- 2001/07/28 10:00 [entrez]
AID - S0379073800004667 [pii]
AID - 10.1016/s0379-0738(00)00466-7 [doi]
PST - ppublish
SO  - Forensic Sci Int. 2001 Sep 1;120(3):165-71. doi: 10.1016/s0379-0738(00)00466-7.