PMID- 11473833
OWN - NLM
STAT- MEDLINE
DCOM- 20010920
LR  - 20211203
IS  - 1471-4906 (Print)
IS  - 1471-4906 (Linking)
VI  - 22
IP  - 8
DP  - 2001 Aug
TI  - Designer dendritic cells for tolerance induction: guided not misguided missiles.
PG  - 437-42
AB  - Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that play 
      crucial roles as initiators and modulators of adaptive immune responses. Although 
      DC-based vaccines have been utilized successfully to generate cytolytic T-cell 
      activity against tumor antigens (Ags), evidence has accumulated that DCs also 
      have potent capabilities to tolerize T cells in an Ag-specific manner. DCs 
      cultured in the laboratory can suppress auto- or alloimmunity. Current and 
      prospective strategies to promote this inherent tolerogenic potential of DCs 
      might prove to be important for the therapy of transplant rejection and 
      autoimmune diseases.
FAU - Hackstein, H
AU  - Hackstein H
AD  - Thomas E. Starzl Transplantation Institute, University of Pittsburgh, W1544 BST, 
      200 Lothrop Street, Pittsburgh, PA 15213, USA.
FAU - Morelli, A E
AU  - Morelli AE
FAU - Thomson, A W
AU  - Thomson AW
LA  - eng
GR  - AI1011/AI/NIAID NIH HHS/United States
GR  - DK 49475/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Trends Immunol
JT  - Trends in immunology
JID - 100966032
SB  - IM
CIN - Trends Immunol. 2001 Oct;22(10):546-7. PMID: 11702722
MH  - Animals
MH  - Autoimmune Diseases/therapy
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - Cell Differentiation
MH  - Dendritic Cells/cytology/*immunology
MH  - Graft Rejection/therapy
MH  - Humans
MH  - *Immune Tolerance/genetics
MH  - Immunosuppression Therapy/*methods
RF  - 52
EDAT- 2001/07/28 10:00
MHDA- 2001/09/21 10:01
CRDT- 2001/07/28 10:00
PHST- 2001/07/28 10:00 [pubmed]
PHST- 2001/09/21 10:01 [medline]
PHST- 2001/07/28 10:00 [entrez]
AID - S1471-4906(01)01959-7 [pii]
AID - 10.1016/s1471-4906(01)01959-7 [doi]
PST - ppublish
SO  - Trends Immunol. 2001 Aug;22(8):437-42. doi: 10.1016/s1471-4906(01)01959-7.