PMID- 11474168
OWN - NLM
STAT- MEDLINE
DCOM- 20010906
LR  - 20171101
IS  - 0301-0171 (Print)
IS  - 0301-0171 (Linking)
VI  - 93
IP  - 1-2
DP  - 2001
TI  - Classifying by colors: FISH-based genome analysis.
PG  - 1-10
AB  - In recent years a fascinating evolution of different multicolor fluorescence in 
      situ hybridization (FISH) technologies could be witnessed. The various approaches 
      to cohybridize multiple DNA probes in different colors opened new avenues for 
      FISH-based automated karyotyping or the simultaneous analysis of multiple defined 
      regions within the genome. These developments had a remarkable impact on 
      microscopy design and the usage of highly sensitive area imagers. In addition, 
      they led to the introduction of new fluorochromes with appropriate filter 
      combinations, refinements of hybridization protocols, novel probe sets, and 
      innovative software for automated chromosome analysis. This paper attempts to 
      summarize the various multicolor approaches and discusses the application of the 
      individual technologies.
CI  - Copyright 2001 S. Karger AG, Basel
FAU - Fauth, C
AU  - Fauth C
AD  - Institut fur Anthropologie und Humangenetik, Ludwig-Maximilians-Universitat 
      Munchen, Goethestrasse 31, D-80336 Munich, Germany.
FAU - Speicher, M R
AU  - Speicher MR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Switzerland
TA  - Cytogenet Cell Genet
JT  - Cytogenetics and cell genetics
JID - 0367735
RN  - 0 (DNA Probes)
SB  - IM
EIN - Cytogenet Cell Genet 2001;94(3-4):254
MH  - Animals
MH  - Chromosome Painting/methods
MH  - Chromosomes/genetics
MH  - Color
MH  - DNA Probes
MH  - Genomics/methods
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Karyotyping/methods
MH  - Physical Chromosome Mapping/*methods
MH  - Sensitivity and Specificity
RF  - 76
EDAT- 2001/07/28 10:00
MHDA- 2001/09/08 10:01
CRDT- 2001/07/28 10:00
PHST- 2001/07/28 10:00 [pubmed]
PHST- 2001/09/08 10:01 [medline]
PHST- 2001/07/28 10:00 [entrez]
AID - 56937 [pii]
AID - 10.1159/000056937 [doi]
PST - ppublish
SO  - Cytogenet Cell Genet. 2001;93(1-2):1-10. doi: 10.1159/000056937.