PMID- 11474195
OWN - NLM
STAT- MEDLINE
DCOM- 20010906
LR  - 20171101
IS  - 0301-0171 (Print)
IS  - 0301-0171 (Linking)
VI  - 93
IP  - 1-2
DP  - 2001
TI  - Chromosomal distribution of the telomere sequence (TTAGGG)(n) in the Equidae.
PG  - 127-30
AB  - Telomeres are a class of repetitive DNA sequences that are located at chromosome 
      termini and that act to stabilize the chromosome ends. The rapid karyotypic 
      evolution of the genus Equus has given rise to ten taxa, all with different 
      diploid chromosome numbers. Using fluorescence in situ hybridization (FISH) we 
      localized the mammalian telomere sequence, (TTAGGG)(n), to the chromosomes of 
      nine equid taxa. TTAGGG signal was located at chromosome termini in all species, 
      however additional signal was seen at interstitial sites on some chromosomes in 
      the Burchell's zebra, Equus quagga burchelli, the Hartmann's zebra, Equus zebra 
      hartmannae, and at large heterochromatin-associated regions on the chromosomes of 
      the donkey, Equus asinus. The interstitial signal in the zebras may be a relic of 
      an ancient telomere-telomere fusion and mark the point at which two ancestral 
      chromosomes may have fused. For the donkey, the heterochromatin-associated signal 
      may represent degenerate telomere-like satellite sequences and identify a second 
      type of satellite DNA for this taxon.
CI  - Copyright 2001 S. Karger AG, Basel
FAU - Lear, T L
AU  - Lear TL
AD  - Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, 
      University of Kentucky, Lexington, KY 40546-0099, USA. equigene@pop.uky.edu
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Cytogenet Cell Genet
JT  - Cytogenetics and cell genetics
JID - 0367735
RN  - 0 (DNA Probes)
RN  - 0 (DNA, Satellite)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - DNA Probes/genetics
MH  - DNA, Satellite/genetics
MH  - Equidae/*genetics
MH  - *Evolution, Molecular
MH  - Fibroblasts
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - *Physical Chromosome Mapping
MH  - Telomere/*genetics
EDAT- 2001/07/28 10:00
MHDA- 2001/09/08 10:01
CRDT- 2001/07/28 10:00
PHST- 2001/07/28 10:00 [pubmed]
PHST- 2001/09/08 10:01 [medline]
PHST- 2001/07/28 10:00 [entrez]
AID - 56964 [pii]
AID - 10.1159/000056964 [doi]
PST - ppublish
SO  - Cytogenet Cell Genet. 2001;93(1-2):127-30. doi: 10.1159/000056964.