PMID- 11478413
OWN - NLM
STAT- MEDLINE
DCOM- 20010906
LR  - 20061115
IS  - 1081-5589 (Print)
IS  - 1081-5589 (Linking)
VI  - 49
IP  - 4
DP  - 2001 Jul
TI  - Monocyte chemoattractant protein-1 and interleukin-8 are increased in 
      bronchopulmonary dysplasia: relation to isolation of Ureaplasma urealyticum.
PG  - 362-9
AB  - BACKGROUND: An exaggerated inflammatory response occurs in infants who 
      subsequently develop bronchopulmonary dysplasia (BPD). Ureaplasma urealyticum 
      (Uu) is frequently isolated from cultures of tracheal secretions obtained from 
      very low birth weight infants and is associated with an increased risk of BPD. 
      METHODS: We examined the relationships between isolation of genital mycoplasmas, 
      tracheal aspirate (TA) interleukin-8 (IL-8), and monocyte chemoattractant 
      protein-1 (MCP-1) concentrations and the development of BPD. Serial TAs were 
      obtained prospectively from 35 very low birth weight infants, and IL-8 and MCP-1 
      concentrations were determined by enzyme-linked immunoadsorbent assay. Tracheal 
      cultures for bacteria and genital mycoplasmas were performed on aspirates 
      obtained during the first 2 days of life. RESULTS: Infants who developed BPD 
      (n=18) were less mature (25.2+/-0.2 vs 27.8+/-0.5 weeks; P<0.001), of lower birth 
      weight (746+/-28 vs 1052+/-41 g; P<0.001), and more likely to have a positive 
      tracheal culture for Uu (39% vs 6%; P=0.026) than those who did not develop BPD 
      (n=17). Tracheal concentrations of IL-8 and MCP-1 were significantly increased in 
      infants who developed BPD (IL-8: P=0.0001; MCP-1: P<0.001, analysis of variance) 
      and correlated with duration of mechanical ventilation and oxygen treatment. 
      Uu-positive infants had an increased incidence of BPD (88% in infants with Uu vs 
      42% in infants without Uu; P=0.020) and had TA concentrations of IL-8 and MCP-1 
      that were significantly increased compared with those of Uu-negative infants. 
      CONCLUSIONS: Increased TA concentrations of IL-8 and MCP-1 during the first 2 
      weeks of life are associated with the development of BPD. Recovery of Uu from TAs 
      is associated with a more robust inflammatory reaction and an increased risk of 
      BPD.
FAU - Baier, R J
AU  - Baier RJ
AD  - Department of Pediatrics, Louisiana State University Health Sciences Center, 
      Shreveport 71130-3932, USA. jbaier@lsuhsc.edu
FAU - Loggins, J
AU  - Loggins J
FAU - Kruger, T E
AU  - Kruger TE
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Investig Med
JT  - Journal of investigative medicine : the official publication of the American 
      Federation for Clinical Research
JID - 9501229
RN  - 0 (Chemokine CCL2)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-8)
SB  - IM
MH  - Bronchopulmonary Dysplasia/etiology/*immunology/*microbiology
MH  - Chemokine CCL2/*metabolism
MH  - Genitalia/microbiology
MH  - Humans
MH  - Infant, Low Birth Weight
MH  - Infant, Newborn
MH  - Inflammation Mediators/metabolism
MH  - Interleukin-8/*metabolism
MH  - Prospective Studies
MH  - Trachea/immunology
MH  - Ureaplasma Infections/complications/immunology
MH  - Ureaplasma urealyticum/immunology/*isolation & purification/pathogenicity
EDAT- 2001/08/02 10:00
MHDA- 2001/09/08 10:01
CRDT- 2001/08/02 10:00
PHST- 2001/08/02 10:00 [pubmed]
PHST- 2001/09/08 10:01 [medline]
PHST- 2001/08/02 10:00 [entrez]
AID - 10.2310/6650.2001.33902 [doi]
PST - ppublish
SO  - J Investig Med. 2001 Jul;49(4):362-9. doi: 10.2310/6650.2001.33902.