PMID- 11480498
OWN - NLM
STAT- MEDLINE
DCOM- 20010809
LR  - 20161219
IS  - 0003-9896 (Print)
IS  - 0003-9896 (Linking)
VI  - 56
IP  - 3
DP  - 2001 May-Jun
TI  - The role of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion 
      molecule-1 (VCAM-1), and regulated on activation, normal T-cell expressed and 
      secreted (RANTES) in the relationship between air pollution and asthma among 
      children.
PG  - 227-33
AB  - To evaluate the role of adhesion molecules and chemokines in the relationship 
      between air pollution and asthma, the authors determined the following in 230 
      children who lived in 4 communities in Japan that had different levels of air 
      pollution: serum concentrations of soluble intercellular adhesion molecule-1 
      (sICAM-1); soluble vascular cell adhesion molecule-1 (sVCAM-1); regulated on 
      activation, normal T-cell expressed and secreted (RANTES); and total 
      immunoglobulin E (IgE). Children with asthma or who exhibited wheezing (n = 115) 
      and nonasthmatic children (n = 115) were studied. Serum concentrations of 
      sICAM-1, sVCAM-1, and RANTES were increased significantly in asthmatic children, 
      compared with nonasthmatic children. Nonasthmatic children with serum IgE levels 
      that were greater than or equal to 250 IU/ml had significantly lower 
      concentrations of sICAM-1 and sVCAM-1 than the other children. The geometric 
      means of sICAM-1 increased as air pollution increased. The results of this study 
      suggest that adhesion molecules or chemokines are associated with asthma and that 
      ICAM-1 may play an important role in the relationship between air pollution and 
      the occurrence of asthma.
FAU - Ando, M
AU  - Ando M
AD  - Department of Public Health, Chiba University School of Medicine, Japan.
FAU - Shima, M
AU  - Shima M
FAU - Adachi, M
AU  - Adachi M
FAU - Tsunetoshi, Y
AU  - Tsunetoshi Y
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arch Environ Health
JT  - Archives of environmental health
JID - 0212627
RN  - 0 (Air Pollutants)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - S7G510RUBH (Nitrogen Dioxide)
SB  - IM
MH  - Air Pollutants/analysis
MH  - Air Pollution/*adverse effects
MH  - Asthma/blood/*epidemiology/*etiology/immunology
MH  - Case-Control Studies
MH  - Chemokine CCL5/*blood
MH  - Child
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Intercellular Adhesion Molecule-1/*blood
MH  - Japan/epidemiology
MH  - Male
MH  - Nitrogen Dioxide/analysis
MH  - Particle Size
MH  - Vascular Cell Adhesion Molecule-1/*blood
EDAT- 2001/08/02 10:00
MHDA- 2001/08/10 10:01
CRDT- 2001/08/02 10:00
PHST- 2001/08/02 10:00 [pubmed]
PHST- 2001/08/10 10:01 [medline]
PHST- 2001/08/02 10:00 [entrez]
AID - 10.1080/00039890109604446 [doi]
PST - ppublish
SO  - Arch Environ Health. 2001 May-Jun;56(3):227-33. doi: 10.1080/00039890109604446.