PMID- 11480584
OWN - NLM
STAT- MEDLINE
DCOM- 20020220
LR  - 20191025
IS  - 0190-2148 (Print)
IS  - 0190-2148 (Linking)
VI  - 27
IP  - 5
DP  - 2001 Jul-Aug
TI  - Pulmonary immunity to ragweed in a Beagle dog model of allergic asthma.
PG  - 433-51
AB  - To create an allergy model in the dog, allergic Beagles with high levels of serum 
      immunoglobulin E (IgE) and eosinophilia were bred; resulting puppies were 
      sensitized to ragweed by intraperitoneal (IP) injection within 24 hours of birth 
      through 22 weeks of age. At least 50% of the puppies developed high levels of 
      serum IgE and eosinophilia. As young adults, 6 of these dogs, and 6 control 
      age-matched, nonallergic, nonimmunized dogs were exposed by inhalation to ragweed 
      twice at 13-day intervals, and a third time 45 days later. Total and 
      ragweed-specific serum IgE and ragweed-specific serum IgG were increased 
      significantly in allergic dogs relative to baseline. Allergic dogs had 
      significantly greater levels of antibody specific for ragweed, as well as higher 
      eosinophil counts in the bronchoalveolar lavage fluid, compared to nonallergic 
      dogs. Airway reactivity to histamine in allergic, but not nonallergic dogs, 
      increased significantly after aerosol exposure to ragweed. After a third exposure 
      to ragweed, airway responses to histamine were elevated in the allergic dogs and 
      remained high for at least 5 months. These results demonstrate the potential of 
      the allergic dog model for investigating the underlying pulmonary immune 
      mechanisms and therapeutic treatment of allergic asthma.
FAU - Redman, T K
AU  - Redman TK
AD  - Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87185-5890, USA.
FAU - Rudolph, K
AU  - Rudolph K
FAU - Barr, E B
AU  - Barr EB
FAU - Bowen, L E
AU  - Bowen LE
FAU - Muggenburg, B A
AU  - Muggenburg BA
FAU - Bice, D E
AU  - Bice DE
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Exp Lung Res
JT  - Experimental lung research
JID - 8004944
RN  - 0 (Allergens)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Plant Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/administration & dosage/*pharmacology
MH  - Animals
MH  - Asthma/chemically induced/*immunology/pathology
MH  - Bronchoalveolar Lavage Fluid/cytology/immunology
MH  - Cell Count
MH  - Disease Models, Animal
MH  - Dogs
MH  - Eosinophils/cytology
MH  - Immunity
MH  - Immunoglobulin E/analysis
MH  - Immunoglobulin G/analysis
MH  - Lung/*immunology/pathology
MH  - Neutrophils/cytology
MH  - Plant Proteins/administration & dosage/pharmacology
EDAT- 2001/08/02 10:00
MHDA- 2002/02/21 10:01
CRDT- 2001/08/02 10:00
PHST- 2001/08/02 10:00 [pubmed]
PHST- 2002/02/21 10:01 [medline]
PHST- 2001/08/02 10:00 [entrez]
AID - 10.1080/019021401300317143 [doi]
PST - ppublish
SO  - Exp Lung Res. 2001 Jul-Aug;27(5):433-51. doi: 10.1080/019021401300317143.