PMID- 11480844
OWN - NLM
STAT- MEDLINE
DCOM- 20011213
LR  - 20170214
IS  - 0961-2033 (Print)
IS  - 0961-2033 (Linking)
VI  - 10
IP  - 7
DP  - 2001
TI  - Polymorphic light eruption and the HLA DRB1*0301 extended haplotype are 
      independent risk factors for cutaneous lupus erythematosus.
PG  - 473-9
AB  - Recent evidence suggests that polymorphic light eruption (PLE) is an inherited 
      photosensitivity disorder which may predispose to cutaneous lupus erythematosus 
      (LE). In this study we examine the relative risk (RR) attributable to the 
      presence of PLE, together with the effect of the major histocompatibility complex 
      (MHC) in the development of cutaneous LE. Eighty-five Caucasian patients with 
      annular subacute cutaneous LE (SCLE) and discoid LE (DLE) were recruited, 
      together with 102 first degree relatives and 200 healthy local Caucasian 
      controls. Symptoms suggestive of PLE were elicited in patients and relatives, and 
      human leukocyte antigen (HLA) typing determined by PCR-SSP. Standard association 
      analysis and family transmission disequilibrium testing (TDT) were then used to 
      compare the HLA frequencies between groups. We found a significant (P < 0.05) 
      association of the HL4 A*01, B*08, DRB1*0301 extended haplotype with both SCLE 
      and DLE and also significant association of DLE with the HLA A*03, B*07, DRB1*15 
      haplotype, with a possible protective effect in SCLE for HLA B*44 and DRB1*04 
      (P=0.002 and 0.001 respectively). Association was observed between PLE and 
      cutaneous LE (P < 0.001), but not between PLE and any HLA allele. From these 
      figures we estimate, for the general population, that the RR of developing SCLE 
      given the presence of (a) PLE, (b) DRB1*0301 and (c) both PLE and DRB1*0301 is 
      3.37, 5.45 and 12.03, respectively. For DLE, equivalent RRs are 3.11, 2.15 and 
      6.94. In conclusion, these data imply the involvement of both PLE and HLA 
      DRB1*0301 in the development of SCLE and DLE. They form a basis for examining the 
      genetic architecture of photosensitivity, some aspects of which may be common to 
      both cutaneous LE and PLE.
FAU - Millard, T P
AU  - Millard TP
AD  - Department of Photobiology, St John's Institute of Dermatology, London, UK. 
      thomas.millard@kcl.ac.uk
FAU - Kondeatis, E
AU  - Kondeatis E
FAU - Vaughan, R W
AU  - Vaughan RW
FAU - Lewis, C M
AU  - Lewis CM
FAU - Khamashta, M A
AU  - Khamashta MA
FAU - Hughes, G R
AU  - Hughes GR
FAU - Hawk, J L
AU  - Hawk JL
FAU - McGregor, J M
AU  - McGregor JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Lupus
JT  - Lupus
JID - 9204265
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*03:01 antigen)
SB  - IM
MH  - Alleles
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - *Haplotypes
MH  - Humans
MH  - Lupus Erythematosus, Cutaneous/*etiology/genetics
MH  - Photosensitivity Disorders/*complications
MH  - Risk Factors
EDAT- 2001/08/02 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/08/02 10:00
PHST- 2001/08/02 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/08/02 10:00 [entrez]
AID - 10.1191/096120301678416024 [doi]
PST - ppublish
SO  - Lupus. 2001;10(7):473-9. doi: 10.1191/096120301678416024.