PMID- 11480848
OWN - NLM
STAT- MEDLINE
DCOM- 20011213
LR  - 20170214
IS  - 0961-2033 (Print)
IS  - 0961-2033 (Linking)
VI  - 10
IP  - 7
DP  - 2001
TI  - Hyperactivity in a mouse model of the antiphospholipid syndrome.
PG  - 496-9
AB  - In the antiphospholipid syndrome (APS), antibodies to a complex of phospholipids 
      and beta2-glycoprotein I (beta2-GPI) are associated with recurrent thromboembolic 
      events, spontaneous abortions, thrombocytopenia and central nervous system (CNS) 
      disturbances. Animals immunized with beta2-GPI develop the systemic 
      manifestations of APS but the involvement of the (CNS) in these animals has not 
      been studied. The objective of the present study was to examine mice with induced 
      experimental APS for behavioral changes. Female Balb/C mice were immunized once 
      with beta2-GPI in complete Freund's adjuvant (CFA) or with CFA alone. Four months 
      after immunization the mice were tested in the staircase apparatus and the 
      following two variables were measured: (1) number of rears: and (2) number of 
      stairs climbed by the mice. Immunization with beta2-GPI resulted in elevated 
      levels of circulating anti-negatively charged phospholipids and anti-beta2-GPI 
      antibodies. The APS mice exhibited hyperactive behavior as reflected by more 
      frequent rears (P < 0.023) and higher number of stairs climbed (P < 0.019) by the 
      mice in 3 min. This simple test demonstrated that experimental APS animals are 
      significantly hyperactive and may serve as a marker for CNS involvement in this 
      model.
FAU - Katzav, A
AU  - Katzav A
AD  - Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv, 
      Israel.
FAU - Pick, C G
AU  - Pick CG
FAU - Korczyn, A D
AU  - Korczyn AD
FAU - Oest, E
AU  - Oest E
FAU - Blank, M
AU  - Blank M
FAU - Shoenfeld, Y
AU  - Shoenfeld Y
FAU - Chapman, J
AU  - Chapman J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Lupus
JT  - Lupus
JID - 9204265
RN  - 0 (Autoantibodies)
RN  - 0 (Glycoproteins)
RN  - 0 (beta 2-Glycoprotein I)
SB  - IM
MH  - Animals
MH  - Antiphospholipid Syndrome/immunology/*psychology
MH  - Autoantibodies/biosynthesis
MH  - Female
MH  - Glycoproteins/immunology
MH  - Immunization
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - *Motor Activity
MH  - beta 2-Glycoprotein I
EDAT- 2001/08/02 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/08/02 10:00
PHST- 2001/08/02 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/08/02 10:00 [entrez]
AID - 10.1191/096120301678416060 [doi]
PST - ppublish
SO  - Lupus. 2001;10(7):496-9. doi: 10.1191/096120301678416060.